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Key Documents

SAB5600038

Sigma-Aldrich

Anti-Gamma H2AX (phospho-Ser139) antibody, Rabbit monoclonal

recombinant, expressed in HEK 293 cells, clone RM224, purified immunoglobulin

Synonym(e):

H2AX Ser139 p, Histone H2AX (phospho ser139)

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About This Item

UNSPSC-Code:
12352203
NACRES:
NA.41

Rekombinant

expressed in HEK 293 cells

Qualitätsniveau

100

Antikörperform

purified immunoglobulin

Antikörper-Produkttyp

primary antibodies

Klon

RM224, monoclonal
recombinant monoclonal

Form

buffered aqueous glycerol solution

Speziesreaktivität

human

Konzentration

~1 mg/mL

Methode(n)

ELISA: 0.2- 1  μg/mL
immunoblotting: 0.5-2 μg/mL
immunocytochemistry: 0.5-2 μg/mL

Isotyp

IgG

NCBI-Hinterlegungsnummer

3014

Versandbedingung

wet ice

Lagertemp.

−20°C

Posttranslationale Modifikation Target

phosphorylation (pSer139)

Angaben zum Gen

human ... H2AX(3014)

Allgemeine Beschreibung

Histone H2AX (H2A histone family member X), a histone variant present in almost all eukaryotes, is coded by H2AFX gene. It is mapped to human chromosome 11q23.2–11q23.3.

Spezifität

This antibody reacts to Histone H2A.X only when phosphorylated at serine 139. No cross reactivity with other phosphorylated histones.

Immunogen

Synthetic peptide corresponding to Phospho-Histone H2AX (Ser139)

Biochem./physiol. Wirkung

H2AX (H2A histone family member X) helps to maintain genome stability. It plays an important role in localisation and structuring of the repair focus. H2AX also plays an active role in supplying the active repair proteins. γH2AX participates in DSB repair. This protein serves as a signal and target of phosphorylation in the spreading phase.

Leistungsmerkmale und Vorteile

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physikalische Form

Solution in phosphate buffered saline containing 50% glycerol, 1% BSA and 0.09% sodium azide.

Haftungsausschluss

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Lagerklassenschlüssel

10 - Combustible liquids

WGK

WGK 2

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Analysenzertifikate (COA)

Suchen Sie nach Analysenzertifikate (COA), indem Sie die Lot-/Chargennummer des Produkts eingeben. Lot- und Chargennummern sind auf dem Produktetikett hinter den Wörtern ‘Lot’ oder ‘Batch’ (Lot oder Charge) zu finden.

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Clinical cancer research : an official journal of the American Association for Cancer Research, 29(22), 4644-4659 (2023-09-19)
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