SAB4503757

Anti-phospho-CREB (pSer¹⁴²) antibody produced in rabbit

affinity isolated antibody

• UNSPSC-Code: 12352203
• NACRES: NA.41

Eigenschaften

• Biologische Quelle: rabbit
• Qualitätsniveau: 100
• Konjugat: unconjugated
• Antikörperform: affinity isolated antibody
• Antikörper-Produkttyp: primary antibodies
• Klon: polyclonal
• Form: buffered aqueous solution
• Mol-Gew.: antigen 36 kDa
• Speziesreaktivität: human, mouse, rat
• Konzentration: ~1 mg/mL
• Methode(n): ELISA: 1:40000; immunofluorescence: 1:100-1:500; immunohistochemistry: 1:50-1:100; western blot: 1:500-1:1000
• NCBI-Hinterlegungsnummer: P16220
• UniProt-Hinterlegungsnummer: P16220
• Versandbedingung: wet ice
• Lagertemp.: −20°C
• Posttranslationale Modifikation Target: phosphorylation (pSer142)
• Angaben zum Gen: human ... CREB1(1385)

Beschreibung

Allgemeine Beschreibung

CREB1 (cAMP response element-binding protein) gene codes for a 43kDa cellular transcription factor, CREB. It has 341 amino acids. It belongs to the basic leucine zipper family of transcription factors. CREB1 is upregulated abundantly in human tissues and is located on human chromosome 2q33–35.

Immunogen

The antiserum was produced against synthesized peptide derived from human CREB around the phosphorylation site of Ser142.

Immunogen Range: 111-160

Biochem./physiol. Wirkung

Knockdown of CREB (cAMP response element-binding protein) promotes apoptosis in pre-B acute lymphoblastic leukemia cells by preventing prosurvival signals. It controls the transcription of antiapoptotic proteins in several cell types. Decrease in CREB phosphorylation leads to malfunction of mitochondria and hypoxia-induced apoptosis in chondrocytes.

Leistungsmerkmale und Vorteile

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Physikalische Form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Haftungsausschluss

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Sicherheitshinweise

• Lagerklassenschlüssel: 10 - Combustible liquids
• WGK: WGK 1
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable