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Merck

R2650

Sigma-Aldrich

Monoclonal Anti-Rac antibody produced in mouse

clone 23A8, purified immunoglobulin, buffered aqueous solution

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About This Item

MDL-Nummer:
UNSPSC-Code:
12352203
NACRES:
NA.41

Biologische Quelle

mouse

Qualitätsniveau

Konjugat

unconjugated

Antikörperform

purified immunoglobulin

Antikörper-Produkttyp

primary antibodies

Klon

23A8, monoclonal

Form

buffered aqueous solution

Mol-Gew.

antigen 21 kDa

Speziesreaktivität

rat, human, mouse

Methode(n)

immunohistochemistry (frozen sections): suitable
immunoprecipitation (IP): suitable
western blot: 0.5-2.0 μg/mL using rat brain microsomal protein preparation

Isotyp

IgG

UniProt-Hinterlegungsnummer

Versandbedingung

dry ice

Lagertemp.

−20°C

Posttranslationale Modifikation Target

unmodified

Angaben zum Gen

Spezifität

The antibody recognizes Rac1 with a slight Rac2 cross-reactivity.

Immunogen

recombinant protein containing the full length human Rac1.

Physikalische Form

Solution in 0.1 M Tris-glycine, pH 7.4, containing 0.15 M NaCl and 0.05% sodium azide with 30% glycerol.

Angaben zur Herstellung

Purified using protein G

Haftungsausschluss

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Lagerklassenschlüssel

10 - Combustible liquids

WGK

WGK 1

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable


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Die Dokumentenbibliothek aufrufen

Michael R Dohn et al.
The Journal of cell biology, 184(3), 437-450 (2009-02-04)
p120-catenin regulates epithelial cadherin stability and has been suggested to function as a tumor suppressor. In this study, we used anchorage-independent growth (AIG), a classical in vitro tumorigenicity assay, to examine the role of p120 in a different context, namely
Laura Barrio-Real et al.
Oncotarget, 9(47), 28612-28624 (2018-07-10)
Phosphatidylinositol-3,4,5-Trisphosphate Dependent Rac Exchange Factor 1 (P-Rex1) is a key mediator of growth factor-induced activation of Rac1, a small GTP-binding protein widely implicated in actin cytoskeleton reorganization. This Guanine nucleotide Exchange Factor (GEF) is overexpressed in human luminal breast cancer
Matthias Rübsam et al.
Nature communications, 8(1), 1250-1250 (2017-11-03)
Generation of a barrier in multi-layered epithelia like the epidermis requires restricted positioning of functional tight junctions (TJ) to the most suprabasal viable layer. This positioning necessitates tissue-level polarization of junctions and the cytoskeleton through unknown mechanisms. Using quantitative whole-mount
Cheng-Wei Lin et al.
Carcinogenesis, 35(11), 2425-2435 (2014-06-28)
Metastatic disease is the leading cause of cancer mortality. Identifying biomarkers and regulatory mechanisms is important toward developing diagnostic and therapeutic tools against metastatic cancer. In this study, we demonstrated that podocalyxin-like 1 (PODXL) is overexpressed in breast tumor cells

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