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Q2876

Sigma-Aldrich

Chinakrin-Senf -dihydrochlorid

≥85% (HPLC)

Synonym(e):

2-Methoxy-6-chlor-9-(4-bis-[β-chlorethyl]-amino-1-methylbutylamino)-acridin -dihydrochlorid, 9-[4-(Bis-(2-chlorethyl)-amino)-1-methylbutylamino]-6-chlor-2-methoxyacridin -dihydrochlorid

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About This Item

Empirische Formel (Hill-System):
C23H28Cl3N3O · 2HCl
CAS-Nummer:
4213-45-0
Molekulargewicht:
541.77
Beilstein:
3819822
EG-Nummer:
224-140-9
MDL-Nummer:
MFCD00043254
UNSPSC-Code:
12352101
PubChem Substanz-ID:
24899329
NACRES:
NA.32

Qualitätsniveau

200

Assay

≥85% (HPLC)

Lagertemp.

−20°C

SMILES String

Cl[H].Cl[H].COc1ccc2nc3cc(Cl)ccc3c(NC(C)CCCN(CCCl)CCCl)c2c1

InChI

1S/C23H28Cl3N3O.2ClH/c1-16(4-3-11-29(12-9-24)13-10-25)27-23-19-7-5-17(26)14-22(19)28-21-8-6-18(30-2)15-20(21)23;;/h5-8,14-16H,3-4,9-13H2,1-2H3,(H,27,28);2*1H

InChIKey

JETDZFFCRPFPDH-UHFFFAOYSA-N

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Allgemeine Beschreibung

Quinacrine mustard dihydrochloride is a fluorescent acridine dye, also abbreviated as QM. In an aqueous solution, the chloroethyl groups rapidly lose chloride ions yielding aziridinium cations. These readily react with the carboxyl, thiol, and heterocyclic ring nitrogen groups of proteins and nucleic acids, or with other nucleophiles.

Anwendung

Quinacrine mustard dihydrochloride is used to stain metaphase chromosomes. Recent applications include the Q-banding of maize and karyotyping of fish. The dye is also used as a vital stain for trypanosomes.

Piktogramme

Skull and crossbonesHealth hazard
GHS06,GHS08

Signalwort

Danger

Gefahreneinstufungen

Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Repr. 2 - Resp. Sens. 1 - Skin Sens. 1

Lagerklassenschlüssel

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Persönliche Schutzausrüstung

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges

Hier finden Sie alle aktuellen Versionen:

Analysenzertifikate (COA)

Lot/Batch Number
WXBD3811V
SLCD2226
SLCB7796
SLBX8180
SLBT9169

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Ahilan Saravanamuthu et al.
The Journal of biological chemistry, 279(28), 29493-29500 (2004-04-23)
Trypanothione reductase is a key enzyme in the trypanothione-based redox metabolism of pathogenic trypanosomes. Because this system is absent in humans, being replaced with glutathione and glutathione reductase, it offers a target for selective inhibition. The rational design of potent
Y Obara et al.
Zoological science, 14(1), 57-64 (1997-02-01)
The small Japanese field mouse Apodemus argenteus has the diploid chromosome number of 46, carrying rather large centromeric C-heterochromatin in most of the 44 autosomes and a large amount of C-heterochromatin in the sex chromosomes: the largest subtelocentric X was
B Ardelt et al.
International journal of oncology, 18(4), 849-853 (2001-03-17)
Chlorophyllin (CHL), the sodium and copper salt of chlorophyll, is capable of inhibiting the mutagenic activity of many chemical compounds. Several mechanisms have been advanced to explain the antimutagenic activity of CHL, including its antioxidant properties and its ability to
Michiko Inuma et al.
Zoological science, 24(6), 588-595 (2007-09-18)
"Delayed QM-fluorescence" refers to the unusual kinetics of fluorescence from most of the C-heterochromatic regions of the chromosomes of the small Japanese field mouse Apodemus argenteus. When stained with quinacrine mustard (QM-stained), these C-heterochromatic regions emit weak fluorescence immediately after
Monika Pietrzak et al.
Biophysical chemistry, 104(1), 305-313 (2003-07-02)
The present study was designed to estimate the ability of chlorophyllin (CHL) to interact with two acridine mutagens, quinacrine mustard (QM) and acridine orange (AO), and with the antitumor anthracycline doxorubicin (Dox). To this end, aqueous solutions of QM, AO
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