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P7561

Sigma-Aldrich

Phentolamin -methansulfonat (Salz)

≥98% (TLC), powder

Synonym(e):

2-(N-[m-Hydroxyphenyl]-p-toluidinomethyl)imidazolin

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About This Item

Lineare Formel:
C17H19N3O · CH3SO3H
CAS-Nummer:
65-28-1
Molekulargewicht:
377.46
EG-Nummer:
200-604-6
MDL-Nummer:
MFCD00134201
UNSPSC-Code:
12352116
PubChem Substanz-ID:
24277798
NACRES:
NA.77

Qualitätsniveau

200

Assay

≥98% (TLC)

Form

powder

Farbe

white to off-white

mp (Schmelzpunkt)

180-182 °C (lit.)

Löslichkeit

ethanol: 26 mg/mL
H2O: 50 mg/mL

Ersteller

Novartis

SMILES String

CS(O)(=O)=O.Cc1ccc(cc1)N(CC2=NCCN2)c3cccc(O)c3

InChI

1S/C17H19N3O.CH4O3S/c1-13-5-7-14(8-6-13)20(12-17-18-9-10-19-17)15-3-2-4-16(21)11-15;1-5(2,3)4/h2-8,11,21H,9-10,12H2,1H3,(H,18,19);1H3,(H,2,3,4)

InChIKey

OGIYDFVHFQEFKQ-UHFFFAOYSA-N

Angaben zum Gen

human ... ADRA1A(148) , ADRA1B(147) , ADRA1D(146) , ADRA2A(150) , ADRA2B(151) , ADRA2C(152)

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Biochem./physiol. Wirkung

α-adrenerger Rezeptor-Antagonist; peripherer Vasodilator

Leistungsmerkmale und Vorteile

This compound was developed by Novartis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Piktogramme

Exclamation mark
GHS07

Signalwort

Warning

Gefahreneinstufungen

Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Zielorgane

Respiratory system

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 3

Persönliche Schutzausrüstung

dust mask type N95 (US), Eyeshields, Gloves

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The Journal of physiology, 601(20), 4539-4556 (2023-09-19)
Currently, all salivary ducts (intercalated, striated and collecting) are assumed to function broadly in a similar manner, reclaiming ions that were secreted by the secretory acinar cells while preserving fluid volume and delivering saliva to the oral cavity. Nevertheless, there
Kazuhisa Honda et al.
Comparative biochemistry and physiology. Part A, Molecular & integrative physiology, 163(3-4), 260-264 (2012-08-23)
We investigated the mechanism underlying central glucagon-induced hyperglycemia and anorexia in chicks. Male 8-day-old chicks (Gallus gallus) were used in all experiments. Intracerebroventricular administration of glucagon in chicks induced hyperglycemia and anorexia from 30 min after administration. However, the plasma
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Canadian journal of physiology and pharmacology, 90(8), 1075-1085 (2012-07-13)
Metabolic syndrome (MS) is a combination of medical disorders that increase the risk of developing cardiovascular disease and diabetes. MS is associated with obesity, increased blood pressure, hyperlipidemia, and hyperglycemia. This study was designed to investigate the pharmacological profile of
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Clinical science (London, England : 1979), 124(6), 413-422 (2012-09-19)
Aging is characterized by increased sympatho-excitation, expressed through both the α-adrenergic and RAAS (renin-angiotensin-aldosterone) pathways. Although the independent contribution of these two pathways to elevated vasoconstriction with age may be substantial, significant cross-talk exists that could produce potentiating effects. To
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