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P7547

Sigma-Aldrich

Phentolamin -hydrochlorid

≥98% (TLC), powder

Synonym(e):

2-[N-(3-Hydroxyphenyl)-4-toluidinomethyl]-2-imidazolin -hydrochlorid, 3-[[(4,5-Dihydro-1H-imidazol-2-yl)-methyl](4-methylphenyl)-amino]-phenol -monohydrochlorid

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About This Item

Empirische Formel (Hill-System):
C17H19N3O · HCl
CAS-Nummer:
73-05-2
Molekulargewicht:
317.81
Beilstein:
3764617
EG-Nummer:
200-793-5
MDL-Nummer:
MFCD00079268
UNSPSC-Code:
12352116
PubChem Substanz-ID:
24898856
NACRES:
NA.77

Qualitätsniveau

200

Assay

≥98% (TLC)

Form

powder

Farbe

white to off-white

Löslichkeit

ethanol: 14 mg/mL
H2O: 20 mg/mL
H2O: unstable (prepare immediately prior to use)

Ersteller

Novartis

SMILES String

Cl[H].Cc1ccc(cc1)N(CC2=NCCN2)c3cccc(O)c3

InChI

1S/C17H19N3O.ClH/c1-13-5-7-14(8-6-13)20(12-17-18-9-10-19-17)15-3-2-4-16(21)11-15;/h2-8,11,21H,9-10,12H2,1H3,(H,18,19);1H

InChIKey

TUEJFGFQYKDAPM-UHFFFAOYSA-N

Angaben zum Gen

human ... ADRA1A(148) , ADRA1B(147) , ADRA1D(146) , ADRA2A(150) , ADRA2B(151) , ADRA2C(152)

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Biochem./physiol. Wirkung

α-Adrenoceptor-Antagonist; peripherer Vasodilator

Leistungsmerkmale und Vorteile

This compound is featured on the Potassium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by Novartis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Lagerung und Haltbarkeit

Protect From Light.

Piktogramme

Exclamation mark
GHS07

Signalwort

Warning

H-Sätze

H302

Gefahreneinstufungen

Acute Tox. 4 Oral

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Persönliche Schutzausrüstung

dust mask type N95 (US), Eyeshields, Gloves

Analysenzertifikate (COA)

Suchen Sie nach Analysenzertifikate (COA), indem Sie die Lot-/Chargennummer des Produkts eingeben. Lot- und Chargennummern sind auf dem Produktetikett hinter den Wörtern ‘Lot’ oder ‘Batch’ (Lot oder Charge) zu finden.

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Wei Zhang et al.
Drug discoveries & therapeutics, 8(1), 11-17 (2014-03-22)
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Kazuhisa Honda et al.
Comparative biochemistry and physiology. Part A, Molecular & integrative physiology, 163(3-4), 260-264 (2012-08-23)
We investigated the mechanism underlying central glucagon-induced hyperglycemia and anorexia in chicks. Male 8-day-old chicks (Gallus gallus) were used in all experiments. Intracerebroventricular administration of glucagon in chicks induced hyperglycemia and anorexia from 30 min after administration. However, the plasma
Zachary Barrett-O'Keefe et al.
Clinical science (London, England : 1979), 124(6), 413-422 (2012-09-19)
Aging is characterized by increased sympatho-excitation, expressed through both the α-adrenergic and RAAS (renin-angiotensin-aldosterone) pathways. Although the independent contribution of these two pathways to elevated vasoconstriction with age may be substantial, significant cross-talk exists that could produce potentiating effects. To
J Daniel Obray et al.
Frontiers in cellular neuroscience, 16, 944243-944243 (2022-07-30)
Dopamine (DA) is a cell-signaling molecule that does not readily cross the blood-brain barrier. Despite this, peripherally administered DA enhances DA levels in the nucleus accumbens and alters DA-related behaviors. This study was designed to investigate whether DA subtype-2 receptors
Kangbin Zhou et al.
Canadian journal of physiology and pharmacology, 90(8), 1075-1085 (2012-07-13)
Metabolic syndrome (MS) is a combination of medical disorders that increase the risk of developing cardiovascular disease and diabetes. MS is associated with obesity, increased blood pressure, hyperlipidemia, and hyperglycemia. This study was designed to investigate the pharmacological profile of
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