P2116

Pirfenidon

≥97% (HPLC), powder, antifibrotic agent

• Synonym(e): 5-Methyl-1-phenyl-2-(1H)-pyridon
• Empirische Formel (Hill-System): C₁₂H₁₁NO
• CAS-Nummer: 53179-13-8
• Molekulargewicht: 185.22
• MDL-Nummer: MFCD00866047
• UNSPSC-Code: 12352200
• PubChem Substanz-ID: 24278625
• NACRES: NA.77

Eigenschaften

• Produktbezeichnung: Pirfenidon, ≥97% (HPLC)
• Qualitätsniveau: 100
• Assay: ≥97% (HPLC)
• Form: powder
• Löslichkeit: H₂O: >10 mg/mL at 60 °C (warming for 30 minutes); DMSO: >20 mg/mL
• Ersteller: Shionogi
• SMILES String: O=C(C=CC(C)=C1)N1C2=CC=CC=C2
• InChI: 1S/C12H11NO/c1-10-7-8-12(14)13(9-10)11-5-3-2-4-6-11/h2-9H,1H3
• InChIKey: ISWRGOKTTBVCFA-UHFFFAOYSA-N

Beschreibung

Allgemeine Beschreibung

Pirfenidone (5-methyl-1-phenyl-2-[1H]-pyridone) is a synthetic derivative of pyridine.

Anwendung

Pirfenidone has been used:

• as a post-operative eye drop in rabbits to analyse its antifibrotic effect to improve glaucoma filtration surgery
• as an anti-scarring agent to examine whether it affects the foreign body reaction after glaucoma drainage device (GDD) implantation in a rabbit
• to test its antifibrotic potential in primary cultures of human orbital fibroblasts (hOFs)
• as tumor necrosis factor (TNFα) inhibitor to study its effect in hypoxia

Biochem./physiol. Wirkung

Pirfenidone inhibits collagen production and fibroblast proliferation. It has shown antifibrotic and anti-inflammatory properties in variety of animal models of pulmonary fibrosis, and in clinical trials.

Pirfenidone is used to treat idiopathic pulmonary fibrosis (IPF). It helps to decrease the weakening of lung function decline and ameliorate progression-free survival. Pirfenidone can repress the multiplication and contraction of collagen of human tenon′s fibroblasts.

Leistungsmerkmale und Vorteile

This compound was developed by Shionogi. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Sicherheitshinweise

• Piktogramme: GHS07
• Signalwort: Warning
• H-Sätze: H302
• P-Sätze: P264 - P270 - P301 + P312 - P501
• Gefahreneinstufungen: Acute Tox. 4 Oral
• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• Persönliche Schutzausrüstung: dust mask type N95 (US), Eyeshields, Gloves