O9765

Orientin

≥97% (HPLC)

• Synonym(e): 8-β-D-Glucopyranosyl-3′,4′,5,7-tetrahydroxyflavon, Luteolin-8-C-β-D-glucopyranosid, Luteolin-8-glucosid, Lutexin
• Empirische Formel (Hill-System): C₂₁H₂₀O₁₁
• CAS-Nummer: 28608-75-5
• Molekulargewicht: 448.38
• MDL-Nummer: MFCD00017432
• UNSPSC-Code: 12352205
• PubChem Substanz-ID: 329818945
• NACRES: NA.25

Eigenschaften

• Qualitätsniveau: 100
• Assay: ≥97% (HPLC)
• Form: powder
• Farbe: yellow
• Löslichkeit: 1 M NaOH: 1 mg/mL, clear, yellow-orange
• Anwendung(en): metabolomics; vitamins, nutraceuticals, and natural products
• Lagertemp.: 2-8°C
• SMILES String: OC[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c2c(O)cc(O)c3C(=O)C=C(Oc23)c4ccc(O)c(O)c4
• InChI: 1S/C21H20O11/c22-6-14-17(28)18(29)19(30)21(32-14)16-11(26)4-10(25)15-12(27)5-13(31-20(15)16)7-1-2-8(23)9(24)3-7/h1-5,14,17-19,21-26,28-30H,6H2/t14-,17-,18+,19-,21+/m1/s1
• InChIKey: PLAPMLGJVGLZOV-VPRICQMDSA-N

Beschreibung

Allgemeine Beschreibung

Orientin (ORI) is a luteolin derivative and water soluble 8-C-glucoside dietary flavone. It has one ketone, two ether, and phenyl groups in its chemical structure. Orientin is sourced from many medicinal plants such as Ocimum sanctum (holy basil), Phyllostachys species (bamboo leaves), Passiflora species, Trollius species, etc.

Anwendung

Orientin has been used:

• as an anti-inflammatory and anti-proliferative agent to test its protective effects against 1,2-dimethyl hydrazine (DMH)-induced colorectal cancer in rats model
• as a flavanoid to investigate its protective effects against mitochondrial dysfunction on antimycin-A induced murine C2C12 skeletal muscle cells
• as a potential endonuclease inhibitor of influenza polymerase PA subunit

Biochem./physiol. Wirkung

Orientin displays neuroprotective effects against hydrogen peroxide-induced SH-SY5Y neuroblastoma cells. It exerts antioxidant, anti-inflammation, antiaging, antidepressant-like, vasodilation, vasorelaxant, and cardioprotective effects.

Flavonoidglycoside aus Kohlpalmen, Trollblumen und Passionsblumen. Antiviraler Wirkstoff, antimikrobielle und antioxidative Wirkung. Radioprotektiv.

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable