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Merck

N1537

Sigma-Aldrich

NU7026

≥98% (HPLC), solid

Synonym(e):

2-(Morpholin-4-yl)-benzo[h]chromen-4-one

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About This Item

Empirische Formel (Hill-System):
C17H15NO3
CAS-Nummer:
Molekulargewicht:
281.31
MDL-Nummer:
UNSPSC-Code:
12352200
PubChem Substanz-ID:
NACRES:
NA.77

Qualitätsniveau

Assay

≥98% (HPLC)

Form

solid

Farbe

tan

Löslichkeit

DMSO: soluble 3 mg/mL at 60 °C
H2O: insoluble

Versandbedingung

wet ice

Lagertemp.

2-8°C

SMILES String

O=C1C=C(Oc2c1ccc3ccccc23)N4CCOCC4

InChI

1S/C17H15NO3/c19-15-11-16(18-7-9-20-10-8-18)21-17-13-4-2-1-3-12(13)5-6-14(15)17/h1-6,11H,7-10H2

InChIKey

KKTZALUTXUZPSN-UHFFFAOYSA-N

Anwendung

NU7026 has been used:
  • as a DNA-dependent protein kinase (DNA-PK) inhibitor, to pre-treat colon cancer cell
  • in kinase inhibitor experiments for treating zygotes with visible pronuclei post 20 h-human chorionic gonadotropin (hCG)
  • to determine its influence on cytotoxicity of dibenzo[def,p]chrysene on HepG2 cells

Potent, ATP-competitive. IC50 = 0.23 μM. Selectivity over other PI3K-related kinases (IC50 = 13 μM for PI3K and >100 μM for ATM and ATR).

Biochem./physiol. Wirkung

Cell permeable, small molecule benzochromenone inhibitor of DNA-PK (DNA dependent protein kinase).

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Persönliche Schutzausrüstung

Eyeshields, Gloves, type N95 (US)


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Die Dokumentenbibliothek aufrufen

Soichiro Shiga et al.
Biochemical and biophysical research communications, 521(3), 668-673 (2019-11-05)
Presence of unperfused regions containing cells under hypoxia and nutrient starvation; contributes to radioresistance in solid human tumors. We have previously reported that cultured cells; under nutrient starvation show resistance to ionizing radiation compare with cells under normal; condition, and
Rachel E Doherty et al.
Cancers, 11(9) (2019-09-05)
Uveal melanoma (UM) is the most common primary intraocular tumour in adults, with a mean survival of six months following metastasis. The survival rates have not improved in over 30 years. This study has shown that sister chromatid exchange (SCE)
Takeshi Yasuda et al.
Genes to cells : devoted to molecular & cellular mechanisms, 26(5), 328-335 (2021-02-25)
SIRT2 and SIRT3 protein deacetylases maintain genome integrity and stability. However, their mechanisms for maintaining the genome remain unclear. To examine the roles of SIRT2 and SIRT3 in DSB repair, I-SceI-based GFP reporter assays for HR, single-strand annealing (SSA) and
The influence of ATM, ATR, DNA-PK inhibitors on the cytotoxic and genotoxic effects of dibenzo [def, p] chrysene on human hepatocellular cancer cell line HepG2
Spryszynska S, et al.
Mutation Research. Genetic Toxicology and Environmental Mutagenesis, 791, 12-24 (2015)
Hideaki Ogiwara et al.
PloS one, 6(12), e28756-e28756 (2011-12-24)
Non-homologous end joining (NHEJ) is a major pathway for the repair of DNA double strand break (DSBs) with incompatible DNA ends, which are often generated by ionizing irradiation. In vitro reconstitution studies have indicated that NHEJ of incompatible DNA ends

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