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Wichtige Dokumente
MAK138
Autophagy Assay Kit
sufficient for 200 fluorometric tests
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About This Item
UNSPSC-Code:
12161503
NACRES:
NA.84
Empfohlene Produkte
Verwendung
sufficient for 200 fluorometric tests
Nachweisverfahren
fluorometric
Relevante Krankheit(en)
cancer; immunological diseases
Lagertemp.
−20°C
Verwandte Kategorien
Allgemeine Beschreibung
Autophagy is an evolutionarily conserved degradation process that targets long-lived proteins, organelles, and other cytoplasmic components for degradation via the lysosomal pathway. Activation of the autophagy pathway is required for multiple cellular roles, including survival during starvation, the clearance of intracellular components, development, and immunity.
Anwendung
- Inhibitory Effect of Ursolic Acid on Proliferation and Migration of Renal Carcinoma Cells and Its Mechanism.: This study explores the inhibitory effects of ursolic acid on the proliferation and migration of renal carcinoma cells. The use of an autophagy assay kit was instrumental in demonstrating that ursolic acid induces autophagy, leading to decreased cell viability and migration. These findings highlight the potential of ursolic acid as a therapeutic agent in renal carcinoma through the modulation of autophagy (Lyu et al., 2022).
Eignung
This kit is suitable for the detection of autophagy in mammalian cells by fluorescence microscopy and fluorescence microplate readers.
Prinzip
The Autophagy Assay kit provides a simple and direct procedure for measuring autophagy in a variety of cell types using a proprietary fluorescent autophagosome marker (λex = 333/λem = 518 nm).
Lagerklassenschlüssel
10 - Combustible liquids
WGK
WGK 2
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Yao Liu et al.
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Continuous activation of angiotensin II (Ang II) induces renal vascular endothelial dysfunction, inflammation and oxidative stress, all of which may contribute to renal damage. MicroRNAs (miRs/miRNAs) play a crucial regulatory role in the pathogenesis of hypertensive nephropathy (HN). The present
Autophagy: machinery and regulation.
Yin Z, et al.
Microbial cell, 3(12), 588-588 (2016)
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Autophagy and apoptosis are powerful regulators of multiple facets of cellular metabolism and homeostasis. Here, we uncover that galanin, a pleiotropic peptide, regulates cardiac autophagy and deactivates apoptotic cell death through the Forkhead box protein O1 (FoxO1) pathway. In hypertrophied
Autophagy in the pathogenesis of disease.
Levine B and Guido K
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Mohd Javed Akhtar et al.
Nanomaterials (Basel, Switzerland), 10(9) (2020-08-30)
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