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M6690
MDL 28170
≥90% (TLC)
Synonym(e):
Calpain Inhibitor III
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About This Item
Empirische Formel (Hill-System):
C22H26N2O4
CAS-Nummer:
Molekulargewicht:
382.45
MDL-Nummer:
UNSPSC-Code:
12352200
PubChem Substanz-ID:
NACRES:
NA.77
Empfohlene Produkte
Qualitätsniveau
Assay
≥90% (TLC)
Zusammensetzung
Peptide Content, >90%
Löslichkeit
DMSO: 26 mg/mL
H2O: insoluble
methanol: soluble
Versandbedingung
wet ice
Lagertemp.
2-8°C
SMILES String
[H]C(=O)C(Cc1ccccc1)NC(=O)[C@@H](NC(=O)OCc2ccccc2)C(C)C
InChI
1S/C22H26N2O4/c1-16(2)20(24-22(27)28-15-18-11-7-4-8-12-18)21(26)23-19(14-25)13-17-9-5-3-6-10-17/h3-12,14,16,19-20H,13,15H2,1-2H3,(H,23,26)(H,24,27)/t19?,20-/m0/s1
InChIKey
NGBKFLTYGSREKK-ANYOKISRSA-N
Angaben zum Gen
human ... CAPN1(823) , CAPN2(824)
Amino Acid Sequence
Z-Val-Phe-al
Anwendung
MDL 28170 has been used as a calpain inhibitor:
- to study its effects on neuroinflammation and necroptosis in rat model of cardiac arrest
- to analyze its effects on the degradation of neuronal nitric oxide synthase (nNOS) in beef semimembranosus muscle
- to study its protective effects against traumatic brain injury and survival of bone marrow-derived mesenchymal stem cells (BMSCs) in rat brain
Biochem./physiol. Wirkung
MDL 28170 exhibits neuroprotective effects against spinal cord injury, focal cerebral ischemia, and neonatal hypoxia-ischemia in rats. It also shows anti-inflammatory and anti-neurodegenerative properties. MDL 28170 crosses the blood-brain barrier and penetrates readily through the cell membranes.
MDL 28170 is a potent cell permeable calpain I and II inhibitor; reduces capsaicin-mediated cell death in cultured dorsal root ganglion neurons. Reduced occurrence of apoptosis in H2O2 and A23187 treated PC12 cells. γ-secretase-inhibitor.
Lagerklassenschlüssel
11 - Combustible Solids
WGK
WGK 3
Flammpunkt (°F)
Not applicable
Flammpunkt (°C)
Not applicable
Persönliche Schutzausrüstung
Eyeshields, Gloves, type N95 (US)
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The cytoskeletal and neuronal protective effects of early treatment with the blood-brain barrier- and cell-permeable calpain inhibitor MDL-28170 was examined in the controlled cortical impact (CCI) traumatic brain injury (TBI) model in male CF-1 mice. This was preceded by a
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