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M5269
Moniliformin sodium salt from Fusarium proliferatum
Synonym(e):
1-Hydroxycyclobut-1-ene-3,4-dione
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About This Item
Lineare Formel:
C4HO3Na
CAS-Nummer:
Molekulargewicht:
120.04
MDL-Nummer:
UNSPSC-Code:
12352200
PubChem Substanz-ID:
NACRES:
NA.77
Empfohlene Produkte
Qualitätsniveau
Lagertemp.
2-8°C
SMILES String
O=C1C(C=C1[O-])=O.[Na+]
InChI
1S/C4H2O3.Na/c5-2-1-3(6)4(2)7;/h1,5H;/q;+1/p-1
InChIKey
FERDNJVXTWPNSA-UHFFFAOYSA-M
Allgemeine Beschreibung
Moniliformin (MON), a mycotoxin and small ionic molecule, is present in various Fusarium species including Fusarium avenaceum, Fusarium subglutinans and Fusarium proliferatum. It is present as sodium or potassium salt of semisquaric acid naturally. MON is also present in maize and small-grain cereals.
Anwendung
Moniliformin sodium salt from Fusarium proliferatum has been used as a mycotoxin standard:
- to test its acute oral toxicity in mice
- to test its subacute toxic effects in rats
- in characterizing mycotoxins from Aspergillus
Biochem./physiol. Wirkung
Moniliformin (MON) is implicated for its toxic potential and may lead to respiratory distress and progressive muscular weakness in rats. It inhibits the tricarboxylic acid (TCA) cycle oxidation step. By acting as a pyruvate substrate, MON effectively inhibits thiamine pyrophosphate cofactor dependant enzymes and blocks the gluconeogenesis pathway. ) Furthermore, MON also inhibits glutathione peroxidase and glutathione reductase leading to oxidative stress in myoblast.
Signalwort
Danger
H-Sätze
P-Sätze
Gefahreneinstufungen
Acute Tox. 3 Oral
Lagerklassenschlüssel
6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
WGK
WGK 3
Flammpunkt (°F)
Not applicable
Flammpunkt (°C)
Not applicable
Persönliche Schutzausrüstung
Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
Analysenzertifikate (COA)
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Katharina Walburga von Bargen et al.
Journal of agricultural and food chemistry, 60(14), 3586-3591 (2012-03-21)
Moniliformin is a mycotoxin produced by fungi of the Fusarium genus and occurs as a contaminant of different cereals worldwide. This study describes the first application of isotopically labeled (13)C(2)-moniliformin for the analysis of moniliformin in cereals. Moniliformin is a
H R Burmeister et al.
Applied and environmental microbiology, 37(1), 11-13 (1979-01-01)
Fusarium moniliforme NRRL 6322 produced about 600 mg of recoverable moniliformin, a mycotoxic metabolite, per kg of corn grit medium. The moniliformin was extracted from the grits with methanol, purified by preparative thin-layer chromatography, and crystallized from ether. The 50%
An Zhang et al.
Journal of Zhejiang University. Science. B, 11(3), 200-208 (2010-03-06)
To investigate the effects of mycotoxin moniliformin (MON) on the metabolism of aggrecan and type II collagen in human chondrocytes in vitro and the relationship between MON and Kashin-Beck disease (KBD). Human chondrocytes were isolated and cultured on bone matrix
A Waskiewicz et al.
Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment, 27(5), 608-615 (2010-05-11)
The principal aim of this study was to estimate the formation of fumonisins (FB(1) and FB(2)), moniliformin (MON), and ergosterol (ERG) by Fusarium oxysporum and Fusarium proliferatum, while the formation of beauvericin (BEA) was estimated by the latter Fusarium species
Silvio Uhlig et al.
International journal of food microbiology, 119(1-2), 17-24 (2007-09-22)
The Fusarium species complex found on small-grain cereals in Northern Europe is largely dominated by F. avenaceum, while other important species include F. tricinctum, F. poae, F. culmorum and F. graminearum. The dominance of F. avenaceum has in recent years
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