M2727

Mexiletin -hydrochlorid

≥98% (GC), powder, sodium channel blocker

• Synonym(e): 1-(2,6-Dimethylphenoxy)-2-propanamin -hydrochlorid
• Empirische Formel (Hill-System): C₁₁H₁₇NO · HCl
• CAS-Nummer: 5370-01-4
• Molekulargewicht: 215.72
• EG-Nummer: 250-825-7
• MDL-Nummer: MFCD00216024
• UNSPSC-Code: 12352200
• PubChem Substanz-ID: 24278542
• NACRES: NA.77

Eigenschaften

• product name: Mexiletin -hydrochlorid, powder
• Assay: ≥98% (GC)
• Qualitätsniveau: 200
• Form: powder
• Farbe: white to off-white
• Löslichkeit: methanol: 50 mg/mL
• Ersteller: Boehringer Ingelheim
• Lagertemp.: 2-8°C
• SMILES String: Cl[H].CC(N)COc1c(C)cccc1C
• InChI: 1S/C11H17NO.ClH/c1-8-5-4-6-9(2)11(8)13-7-10(3)12;/h4-6,10H,7,12H2,1-3H3;1H
• InChIKey: NFEIBWMZVIVJLQ-UHFFFAOYSA-N
• Angaben zum Gen: human ... SCN10A(6336) , SCN11A(11280) , SCN1A(6323) , SCN2A(6326) , SCN3A(6328) , SCN4A(6329) , SCN5A(6331) , SCN7A(6332) , SCN8A(6334) , SCN9A(6335)

Beschreibung

Allgemeine Beschreibung

Mexiletine is a class I B antiarrhythmic and an analog of lidocaine. It has shelf life of 10-12 hours and is metabolized in liver and eliminated post reduction, oxidation deamination or conjugation.

Anwendung

Mexiletine hydrochloride has been used as a sodium channel blocker:

• expressed in chinese hamster ovary cells
• in human embryonic kidney (HEK) cells for whole cell patch-clamp studies
• electrophysiology studies in HEK cells expressing Nav1.7 protein

Biochem./physiol. Wirkung

Mexiletine is a potent sodium channel blocker. It is a cardiac antiarrhythmic and is used as an adjuvant in headache and neuropathic pain Mexiletine is used for treating myotonia in sodium channelopathies and reduces the cardiac action potential depolarization but shows no impact on atrial refractoriness. Its inhibitory effect on sodium channels is effective in treating potassium aggravated myotonia.

Leistungsmerkmale und Vorteile

This compound was developed by Boehringer Ingelheim. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Sicherheitshinweise

• Piktogramme: GHS07
• Signalwort: Warning
• H-Sätze: H302
• P-Sätze: P264 - P270 - P301 + P312 - P501
• Gefahreneinstufungen: Acute Tox. 4 Oral
• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable