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B5016

Sigma-Aldrich

Bepridil -hydrochlorid

powder

Synonym(e):

1-Isobutoxy-2-pyrrolidino-3-(N-benzylanilino)propane hydrochloride

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About This Item

Empirische Formel (Hill-System):
C24H34N2O · HCl
CAS-Nummer:
68099-86-5
Molekulargewicht:
403.00
MDL-Nummer:
MFCD00065498
UNSPSC-Code:
12352202
PubChem Substanz-ID:
24277824
NACRES:
NA.77

Form

powder

Qualitätsniveau

100

Ersteller

Johnson & Johnson

SMILES String

Cl.CC(C)COCC(CN(Cc1ccccc1)c2ccccc2)N3CCCC3

InChI

1S/C24H34N2O.ClH/c1-21(2)19-27-20-24(25-15-9-10-16-25)18-26(23-13-7-4-8-14-23)17-22-11-5-3-6-12-22;/h3-8,11-14,21,24H,9-10,15-20H2,1-2H3;1H

InChIKey

JXBBWYGMTNAYNM-UHFFFAOYSA-N

Angaben zum Gen

human ... CACNA1A(773) , CACNA1B(774) , CACNA1C(775) , CACNA1D(776) , CACNA1E(777) , CACNA1F(778) , CACNA1G(8913) , CACNA1H(8912) , CACNA1I(8911) , CACNA1S(779) , CACNA2D1(781) , CACNA2D2(9254) , CACNA2D3(55799) , CACNA2D4(93589) , CACNB1(782) , CACNB2(783) , CACNB3(784) , CACNB4(785) , CACNG1(786) , CACNG2(10369) , CACNG3(10368) , CACNG4(27092) , CACNG5(27091) , CACNG6(59285) , CACNG7(59284) , CACNG8(59283)

Biochem./physiol. Wirkung

Non-selective calcium channel blocker and class IV antiarrhythmic agent; inhibits Na+-Ca2+ exchange; inhibits growth of brain tumor cells in vitro.

Leistungsmerkmale und Vorteile

This compound was developed by Johnson & Johnson. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 2

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Persönliche Schutzausrüstung

Eyeshields, Gloves, type N95 (US)

Analysenzertifikate (COA)

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Hiroki Takanari et al.
Journal of pharmacological sciences, 115(1), 15-26 (2010-12-16)
Bepridil is effective for conversion of atrial fibrillation to sinus rhythm and in the treatment of drug-refractory ventricular tachyarrhythmias. We investigated the effects of bepridil on electrophysiological properties and spiral-wave (SW) reentry in a 2-dimensional ventricular muscle layer of isolated
Masato Murakami et al.
Journal of cardiovascular pharmacology, 56(4), 389-395 (2010-07-14)
It has been reported that bepridil prevents ventricular fibrillation (VF) in patients with Brugada syndrome, but the comparative efficacy with and without mutation in the SCN5A gene has not been elucidated. The purpose of this study was to assess the
Stefan Mitterreiter et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 30(26), 8974-8983 (2010-07-02)
The two proteases beta-secretase and gamma-secretase generate the amyloid beta peptide and are drug targets for Alzheimer's disease. Here we tested the possibility of targeting the cellular environment of beta-secretase cleavage instead of the beta-secretase enzyme itself. beta-Secretase has an
Miki Yamase et al.
Heart (British Cardiac Society), 98(14), 1067-1071 (2012-06-13)
Pharmacological conversion to sinus rhythm is generally difficult to achieve, particularly in long-lasting persistent atrial fibrillation (AF). The purpose of this study is to compare the effectiveness of two agents, amiodarone and bepridil, in achieving conversion to sinus rhythm in
P Kischel et al.
British journal of pharmacology, 128(3), 767-773 (1999-10-12)
1. Bepridil (BPD) is a pharmacological compound able to bind to the Ca2+ sensor protein troponin C (TnC), which triggers skeletal muscle contraction upon Ca2+-binding. BPD can thereby modulate the Ca2+-affinity of this protein. 2. The Ca2+-sensitizing action of bepridil
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