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Key Documents

M1574

Sigma-Aldrich

Miglitol

Synonym(e):

1-(2-Hydroxyethyl)-2-(hydroxymethyl)piperidine-3,4,5-triol

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About This Item

Empirische Formel (Hill-System):
C8H17NO5
CAS-Nummer:
72432-03-2
Molekulargewicht:
207.22
EG-Nummer:
276-661-6
UNSPSC-Code:
12352205
NACRES:
NA.25

Biologische Quelle

synthetic (organic)

Qualitätsniveau

200

Assay

≥98% (HPLC)

Form

powder

mp (Schmelzpunkt)

142-147  °C

Löslichkeit

water: 5 mg/mL, clear, colorless to faintly yellow

Lagertemp.

room temp

InChI

1S/C8H17NO5/c10-2-1-9-3-6(12)8(14)7(13)5(9)4-11/h5-8,10-14H,1-4H2/t5-,6+,7-,8-/m1/s1

InChIKey

IBAQFPQHRJAVAV-ULAWRXDQSA-N

Allgemeine Beschreibung

Miglitol is an alpha-glucosidase inhibitor used as a glucose-lowering drug in diabetes research.

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 1

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Analysenzertifikate (COA)

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Kazuki Mochizuki et al.
Bioscience, biotechnology, and biochemistry, 74(12), 2470-2474 (2010-12-15)
β(2) integrins (CD11s/CD18) promote the attachment of leukocytes to vascular endothelial cells. We performed in this study sucrose loading to rats with moderate postprandial hyperglycemia with/without once-daily dosing of the α-glucosidase inhibitor, miglitol, for 4 days under 4-h fasting conditions.
Kazuki Mochizuki et al.
Metabolism: clinical and experimental, 60(11), 1560-1565 (2011-05-10)
Otsuka Long-Evans Tokushima Fatty (OLETF) rats, an animal model of type 2 diabetes mellitus, exhibit chronic and slowly progressive hyperglycemia with obesity. In this study, we examined whether dietary supplementation with the α-glucosidase inhibitor miglitol from the preonset stage improves
Kyra Jones et al.
Bioorganic & medicinal chemistry, 19(13), 3929-3934 (2011-06-15)
Inhibition of intestinal α-glucosidases and pancreatic α-amylases is an approach to controlling blood glucose and serum insulin levels in individuals with Type II diabetes. The two human intestinal glucosidases are maltase-glucoamylase and sucrase-isomaltase. Each incorporates two family 31 glycoside hydrolases
Takuo Emoto et al.
The American journal of cardiology, 109(1), 42-46 (2011-09-29)
Repeated postprandial hyperglycemia may play an important role in the development of atherosclerosis by suppressing vascular endothelial function. Although miglitol suppresses the elevation of blood glucose levels shortly after a meal more than other α-glucosidase inhibitors, the effect of 3-month
Kenichi Matsuura et al.
Diabetes technology & therapeutics, 14(5), 423-429 (2012-02-10)
We compared the effects of miglitol as an add-on to bolus insulin and dose-intensified bolus insulin on postprandial glycemic excursions by continuous glucose monitoring (CGM). The glucose levels of 21 type 2 diabetes patients admitted for glycemic control were monitored
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