H2042

Histone H2A human

• Synonym(e): Histone, Human
• CAS-Nummer: 1523001-32-2
• UNSPSC-Code: 12352202
• NACRES: NA.25

Eigenschaften

• Biologische Quelle: human
• Qualitätsniveau: 200
• Rekombinant: expressed in E. coli
• Form: liquid
• Konzentration: 1 mg/mL
• UniProt-Hinterlegungsnummer: Q16777
• Anwendung(en): cell analysis
• Versandbedingung: wet ice
• Lagertemp.: −20°C
• Angaben zum Gen: human ... H2AC20(8338)

Beschreibung

Allgemeine Beschreibung

Histones are highly basic chromatin proteins. They tightly pack and organize eukaryotic DNA to form nucleosomes. A nucleosome comprises an octameric core histone made of a tetramer of histones H3 and H4 with two dimers of histones H2A and H2B. The 147 DNA base pairs are wrapped around the histone complex. H2A consists of a C-terminal tail extending out of the nucleosome core particle.

Anwendung

Histone H2A human has been used as a neutrophil extracellular trap (NET) to study its effects on the membrane integrity and viability of macrophages (MFS) and dendritic cells (DCS). It has also been used in far-western blot analysis for protein identification.

Biochem./physiol. Wirkung

Histones modulate the accessibility of DNA during transcription, DNA replication, DNA repair, and recombination. N and C terminal tails undergo post-translational modifications (PTMs) altering DNA wrapping and chromatin regulation.

Physikalische Form

Supplied in 20 mM Na₃PO₄, pH 7.0, 0.3 M NaCl and 1 mM EDTA

Sicherheitshinweise

• Piktogramme: GHS08
• Signalwort: Danger
• H-Sätze: H350
• P-Sätze: P201 - P308 + P313
• Gefahreneinstufungen: Carc. 1B
• Lagerklassenschlüssel: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable