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H9250
Histon aus Kalbsthymus
Type II-A, lyophilized powder
Synonym(e):
histone type VIII-S
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About This Item
Empfohlene Produkte
Biologische Quelle
bovine (calf) thymus
Qualitätsniveau
Typ
Type II-A
Form
lyophilized powder
Anwendung(en)
cell analysis
Lagertemp.
2-8°C
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Allgemeine Beschreibung
Histones are octameric proteins containing H3, H4, H2A and H2B. It is the core protein around which DNA is wound forming the nucleosome structure. The core histone proteins contain globular domains. Each protein is composed of basic amino acids at its N-terminal. The H2A has an extra amino acid at its C-terminal end forming a histone tail. The nucleosome structure is stabilized by the linker histones during chromatin condensation.
Anwendung
Histone from calf thymus has been used:
- in methyltransferase reaction mixture for methyltransferase assay
- in in vitro binding assay, to explore the potential binding of the MORF4 (mortality factor on chromosome 4) - related gene on chromosome 15 (MRG15) chromo domain with histone
- in in vitro coculture assays, to stimulate liver resident Kupffer cells
Biochem./physiol. Wirkung
The core histones are involved in histone-histone interactions and maintains the organization of the nucleosomal DNA. The histone tail helps in forming higher-order nucleosomal structures. The overall structure and action of chromatin fiber is regulated by histone modifications.
Leistungsmerkmale und Vorteile
Do not confuse Sigma "Type" designations with the "Fraction" designations used by Luck and co-workers.
Angaben zur Herstellung
Unfractionated whole histone
Lagerklassenschlüssel
11 - Combustible Solids
WGK
WGK 3
Flammpunkt (°F)
Not applicable
Flammpunkt (°C)
Not applicable
Analysenzertifikate (COA)
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By means of Silicon Nano Tweezers (SNTs) the effects on the mechanical properties of λ-phage DNA during interaction with calf thymus nucleosome to form an artificial chromatin analog were measured. At a concentration of 100 nM, a nucleosome solution induced a
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