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H1753

Sigma-Aldrich

Hydralazin -hydrochlorid

Synonym(e):

1-Hydrazinophthalazin -hydrochlorid

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About This Item

Empirische Formel (Hill-System):
C8H8N4 · HCl
CAS-Nummer:
304-20-1
Molekulargewicht:
196.64
EG-Nummer:
206-151-0
MDL-Nummer:
MFCD00135998
UNSPSC-Code:
12352200
PubChem Substanz-ID:
24278461
NACRES:
NA.77

Biologische Quelle

synthetic (organic)

Qualitätsniveau

100

Assay

≥99% (TLC)

Form

powder

mp (Schmelzpunkt)

273 °C

Löslichkeit

water: 50 mg/mL

SMILES String

Cl[H].N\N=C1/N=NC=C2C=CC=CC12

InChI

1S/C8H8N4.ClH/c9-11-8-7-4-2-1-3-6(7)5-10-12-8;/h1-5,7H,9H2;1H/b11-8-;

InChIKey

SECXUXOCDLQOBI-MKFZHGHUSA-N

Angaben zum Gen

human ... MAOA(4128) , MAOB(4129)

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Anwendung

Hydralazine hydrochloride has been used:
  • as a vasodilator to study its effects on hypertension in T-cell frequencies in juvenile rats
  • as a semicarbazide-sensitive amine oxidase (SSAO) inhibitor to study its effects on myocardial ischemia-reperfusion (I/R) injury
  • as a vasodilator to study its effects on insulin secretion and glucose tolerance

Biochem./physiol. Wirkung

Hydralazine hydrochloride has therapeutic effects against heart failure and high blood pressure.
Inhibits DNA methyltransferase and modulates epigenetic regulation of gene expression. Non-selective MAO-A/B inhibitor; antihypertensive; semicarbazide-sensitive amine oxidase inhibitor.

Leistungsmerkmale und Vorteile

This compound is featured on the Dopamine and Norepinephrine Metabolism page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Piktogramme

Skull and crossbones
GHS06

Signalwort

Danger

Gefahreneinstufungen

Acute Tox. 3 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Zielorgane

Respiratory system

Lagerklassenschlüssel

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Persönliche Schutzausrüstung

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

Hier finden Sie alle aktuellen Versionen:

Analysenzertifikate (COA)

Lot/Batch Number
MKCT3552
MKCQ8899
MKCR9220
MKCQ2237
MKCM6376

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