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F0287

Sigma-Aldrich

Fibronectin

lyophilized powder, 70 kDa

Synonym(e):

Fibronectin

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About This Item

MDL-Nummer:
MFCD00131062
UNSPSC-Code:
12352202
eCl@ss:
42020141
NACRES:
NA.75

Biologische Quelle

human plasma

Qualitätsniveau

200

Assay

>90% (SDS-PAGE)

Form

lyophilized powder

Mol-Gew.

70 kDa

Verpackung

pkg of 0.5 mg

Methode(n)

cell culture | mammalian: suitable

Verunreinigungen

HIV and HBsAg, source material tested negative
 Small proteolytic fragments, may contain traces

Löslichkeit

water: soluble ≥0.500 mg/mL, clear to slightly hazy, colorless

UniProt-Hinterlegungsnummer

P02751

Versandbedingung

ambient

Lagertemp.

−20°C

Angaben zum Gen

human ... FN1(2335)

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Allgemeine Beschreibung

Fibronectin 1 is a glycoprotein of the extracellular matrix that is coded by FN1 gene. It is expressed in the plasma and at the cell surface. FN1 is mapped to human chromosome 2q35. Proteolytic fragments of fibronectin has a cell binding domain.

Anwendung

Fibronectin Proteolytic Fragment from human plasma has been used in pre adsorbed antibody blocking assay and EC-pericyte tube coassembly.

Biochem./physiol. Wirkung

Fibronectin participates in cell adhesion, growth, migration, wound healing, blood coagulation and metastasis. Mutations in FN1 results in glomerulopathy. It plays an important role in cell attachment and spreading, control of cell cytoskeleton, morphology and differentiation. FN1 is also involved in extracellular matrix formation, hemostasis and thrombosis. Proteolytic fragments of fibronectin plays a vital role in mononuclear phagocyte function.

Vorsicht

The product should be stored at -20°C.

Angaben zur Herstellung

This product is lyophilized from phosphate buffered saline with sucrose as a cryoprotectant. The source material has tested negative for antibody to HIV, HCN, and HBsAg. It is soluble in water at 0.5 mg/mL and yields a clear to slightly hazy solution.

Piktogramme

Exclamation mark
GHS07

Signalwort

Warning

Gefahreneinstufungen

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Zielorgane

Respiratory system

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Analysenzertifikate (COA)

Suchen Sie nach Analysenzertifikate (COA), indem Sie die Lot-/Chargennummer des Produkts eingeben. Lot- und Chargennummern sind auf dem Produktetikett hinter den Wörtern ‘Lot’ oder ‘Batch’ (Lot oder Charge) zu finden.

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Die Dokumentenbibliothek aufrufen

Fibronectin in Health and Disease (2018)
C Penn et al.
Microbial pathogenesis, 17(6), 387-393 (1994-12-01)
Candida albicans yeast cells bind soluble human plasma fibronectin (Fn) through a glycoprotein receptor (adhesin) located on the cell surface. This work demonstrates that a 120 kDa proteolytic fragment of Fn encompassing the cell binding domain binds more avidly to
Mutations F352A and Y528A in human HSP90I? reduce fibronectin association and fibrillogenesis in cell-derived matrices.
Chakraborty, et al.
Cell Stress & Chaperones (2023)
Pericyte recruitment during vasculogenic tube assembly stimulates endothelial basement membrane matrix formation.
Stratman A N, et al.
Blood, 114(24), 5091-5101 (2009)
Ail protein binds ninth type III fibronectin repeat (9FNIII) within central 120 kDa region of fibronectin to facilitate cell binding by Yersinia pestis.
Tsang T M, et al.
The Journal of Biological Chemistry, 287(20), 16759-16767 (2012)
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