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Wichtige Dokumente
E2531
Anti-Erythropoietin antibody produced in rabbit
IgG fraction of antiserum, lyophilized powder
Synonym(e):
Anti-Epo
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About This Item
Empfohlene Produkte
Biologische Quelle
rabbit
Qualitätsniveau
Konjugat
unconjugated
Antikörperform
IgG fraction of antiserum
Antikörper-Produkttyp
primary antibodies
Klon
polyclonal
Form
lyophilized powder
Speziesreaktivität
human
Methode(n)
immunohistochemistry (formalin-fixed, paraffin-embedded sections): 5-15 μg/mL
neutralization: suitable
western blot: 1 μg/mL
UniProt-Hinterlegungsnummer
Lagertemp.
−20°C
Posttranslationale Modifikation Target
unmodified
Angaben zum Gen
human ... EPO(2056)
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Allgemeine Beschreibung
Epo is mainly produced by liver cells in fetal stages, by kidneys under hypoxic conditions; liver and brain also secrete Epo in less amounts. Anti-Erythropoietin antibody specifically reacts with human Erythropoietin. The EPO gene is mapped to human chromosome 7q22.1.
Immunogen
recombinant human erythropoietin expressed in CHO cells.
Anwendung
Anti- Erythropoietin antibody may be used for immunoblotting at a working concentration of 1 μg/mL. For immunohistochemistry, a working concentration of 5-15 μg/mL may be used. The antibody is also suitable for neutralization reactions. Erythropoietin antibody has been used for ELISA in the extracts of leaves of tobacco plant in which recombinant human erythropoietin was expressed. The antibody has also been used for immunoaffinity chromatography to separate the leaf extracts of tobacco expressing recombinant human erythropoietin.
Biochem./physiol. Wirkung
Erythropoietin (Epo) is a pleotropic cytokine that promotes erythropoiesis or proliferation and differentiation of red blood cell precursors. The red blood cell production is stimulated when Epo binds and activates the Epo receptor (EpoR) dimer. EpoR directly regulates the signalling by Jak2, PI3K, NF-κB, STAT5A and STAT5B. Epo also inhibits apoptosis of erythroid progenitors by downregulating Fas (tumor necrosis factor receptor superfamily member 6) and FasL (Fas ligand). The expression of Epo is under the control of the transcription factor hypoxia inducible factor (HIF). Erythropoietin exhibits disease-modifying effects in infectious diseases and chronic inflammatory disorders Anti-Erythropoietin antibody specifically reacts with human Erythropoietin.
Physikalische Form
Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline containing carbohydrates.
Haftungsausschluss
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Lagerklassenschlüssel
11 - Combustible Solids
WGK
WGK 2
Flammpunkt (°F)
Not applicable
Flammpunkt (°C)
Not applicable
Persönliche Schutzausrüstung
Eyeshields, Gloves, type N95 (US)
Analysenzertifikate (COA)
Suchen Sie nach Analysenzertifikate (COA), indem Sie die Lot-/Chargennummer des Produkts eingeben. Lot- und Chargennummern sind auf dem Produktetikett hinter den Wörtern ‘Lot’ oder ‘Batch’ (Lot oder Charge) zu finden.
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Andrew J Conley et al.
Biotechnology and bioengineering, 103(3), 562-573 (2009-03-07)
The demand for recombinant proteins for medical and industrial use is expanding rapidly and plants are now recognized as an efficient, inexpensive means of production. Although the accumulation of recombinant proteins in transgenic plants can be low, we have previously
Molecular definition of a narrow interval at 7q22. 1 associated with myelodysplasia.
Johnson E J, et al.
Blood, 87(9), 3579-3586 (1996)
Farooqahmed S Kittur et al.
Plant cell reports, 31(7), 1233-1243 (2012-03-01)
Erythropoietin (EPO) is a glycoprotein hormone that displays both hematopoietic and tissue-protective functions by binding to two distinct receptors. Recombinant human EPO (rhuEPO) is widely used for the treatment of anemia, but its use for tissue protection is limited because
Andrew J Conley et al.
Plant biotechnology journal, 7(2), 183-199 (2008-12-06)
Human erythropoietin (EPO) is a pleiotropic cytokine with remarkable tissue-protective activities in addition to its well-established role in red blood cell production. Unfortunately, conventional mammalian cell cultures are unlikely to meet the anticipated market demands for recombinant EPO because of
Amit A Joharapurkar et al.
Current research in pharmacology and drug discovery, 3, 100102-100102 (2022-05-17)
Many anemic chronic kidney disease (CKD) patients are refractory to erythropoietin (EPO) effects due to inflammation, deranged iron utilization, and generation of EPO antibodies. This work assessed the effect of desidustat, an inhibitor of hypoxia inducible factor (HIF) prolyl hydroxylase
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