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D8190

Sigma-Aldrich

3′,4′-Dichlorobenzamil hydrochloride

>98% (HPLC)

Synonym(e):

L-594,881

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About This Item

Empirische Formel (Hill-System):
C13H12N7OCl3 · HCl
CAS-Nummer:
928621-15-2
Molekulargewicht:
425.10
MDL-Nummer:
MFCD03839362
UNSPSC-Code:
12352200
PubChem Substanz-ID:
24278390
NACRES:
NA.77

Qualitätsniveau

100

Assay

>98% (HPLC)

Form

solid

Farbe

yellow

Löslichkeit

DMSO: soluble 30 mg/mL
H2O: insoluble

Lagertemp.

2-8°C

SMILES String

NC1=NC(N)=C(Cl)N=C1C(NC(NCC2=CC(Cl)=C(Cl)C=C2)=N)=O.Cl

InChI

1S/C13H12Cl3N7O.ClH/c14-6-2-1-5(3-7(6)15)4-20-13(19)23-12(24)8-10(17)22-11(18)9(16)21-8;/h1-3H,4H2,(H4,17,18,22)(H3,19,20,23,24);1H

InChIKey

LPHAOBPPRPXQLQ-UHFFFAOYSA-N

Biochem./physiol. Wirkung

Inhibits Na+/Ca2+ exchanger, Na+ transport and sarcoplasmic reticulum Ca2+ release channels.

Piktogramme

Exclamation mark
GHS07

Signalwort

Warning

H-Sätze

H302

Gefahreneinstufungen

Acute Tox. 4 Oral

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Persönliche Schutzausrüstung

Eyeshields, Gloves, type N95 (US)

Analysenzertifikate (COA)

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J P Danaceau et al.
The Journal of general physiology, 115(6), 759-768 (2000-06-01)
Olfactory receptor neurons (ORNs) from the squid, Lolliguncula brevis, respond to the odors l-glutamate or dopamine with increases in internal Ca(2+) concentrations ([Ca(2+)](i)). To directly asses the effects of increasing [Ca(2+)](i) in perforated-patched squid ORNs, we applied 10 mM caffeine
C G Ponte et al.
European journal of pharmacology, 391(1-2), 11-20 (2000-03-18)
Dichlorobenzamil, phenamil and other amiloride analogs (1-100 microM) elicit transient tension in rabbit skinned muscle fibers. Tension requires preloading of Ca(2+) into the sarcoplasmic reticulum, is facilitated by low-[Mg(2+)] solutions, abolished by ruthenium red or by functional disruption of the
William Harley et al.
Brain research, 1363, 159-169 (2010-09-28)
Malignant glioma cells maintain an elevated intracellular pH (pH(i)) within hypoxic-ischemic tumor microenvironments through persistent activation of sodium-proton transport (McLean et al., 2000). Amiloride has been reported to selectively kill human malignant glioma cell lines but not primary astrocytes (Hegde
S J Kleene
The Journal of membrane biology, 178(1), 49-54 (2000-11-04)
In vertebrates, cilia on the olfactory receptor neurons have a high density of cyclic-nucleotide-gated (CNG) channels. During transduction of odorous stimuli, cyclic AMP is formed. cAMP gates the CNG channels and this initiates the neuronal depolarization. Here it is shown
B E Galindo et al.
Developmental biology, 221(2), 285-294 (2000-05-03)
Speract, a decapeptide from Strongylocentrotus purpuratus sea urchin eggs, transiently stimulates a membrane guanylyl cyclase and activates a K(+)-selective channel that hyperpolarizes sperm. However, previous studies of sperm and of sperm membrane vesicles reached conflicting conclusions about the mechanisms that
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