D3168
Duramycin from Streptoverticillium cinnamoneus
≥90.0%
Synonym(e):
Duramycin, Lancovutide
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About This Item
Empirische Formel (Hill-System):
C89H125N23O25S3
CAS-Nummer:
Molekulargewicht:
2013.28
MDL-Nummer:
UNSPSC-Code:
51102829
NACRES:
NA.85
Empfohlene Produkte
Qualitätsniveau
Assay
≥90.0%
Form
powder
Löslichkeit
0.1 M HCl: 10 mg/mL
Wirkungsspektrum von Antibiotika
Gram-negative bacteria
Gram-positive bacteria
Wirkungsweise
protein synthesis | interferes
Lagertemp.
2-8°C
Allgemeine Beschreibung
Chemical structure: tetracycline
Anwendung
Duramycin is used to study chloride secretion by cardial, pancreatic and airway epithelial voltage-gated ion channels. It is used to study cystic fibrosis and as a novel phosphatidylethanolamine-binding molecular probe. It is used to stimulate sodium transport in cultured human colonic epithelia.
Biochem./physiol. Wirkung
Duramycin is the smallest known polypeptide since it has only 19 amino acids. It has a defined 3-dimensional binding structure. Duramycin binds phosphatidylethanolamine (PtdE) at a 1:1 ratio with high affinity and exclusive specificity. It enhances chloride secretion in airway epithelium.
Sonstige Hinweise
Keep container tightly closed in a dry and well-ventilated place.
Lagerklassenschlüssel
11 - Combustible Solids
WGK
WGK 3
Flammpunkt (°F)
Not applicable
Flammpunkt (°C)
Not applicable
Persönliche Schutzausrüstung
Eyeshields, Gloves, type N95 (US)
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Ming Zhao et al.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 49(8), 1345-1352 (2008-07-18)
With only 19 amino acids, duramycin is the smallest known polypeptide that has a defined 3-dimensional binding structure. Duramycin binds phosphatidylethanolamine (PtdE) at a 1:1 ratio with high affinity and exclusive specificity. As an abundant binding target, PtdE is a
Jason H Stafford et al.
Neoplasia (New York, N.Y.), 13(4), 299-308 (2011-04-08)
We have previously shown that oxidative stress within the tumor microenvironment causes phosphatidylserine (PS) to redistribute from the inner to the outer membrane leaflet of the endothelial cells (EC) creating a highly specific marker for the tumor vasculature. Because the
Ilka Steiner et al.
Naunyn-Schmiedeberg's archives of pharmacology, 378(3), 323-333 (2008-05-27)
Duramycin (Moli1901) is being developed for the treatment of reduced mucociliary clearance in cystic fibrosis. This study was conducted to estimate lung residence time and systemic exposure and to assess whether duramycin causes an inflammatory response. Six volunteers were administered
Soichiro Matsunaga et al.
Langmuir : the ACS journal of surfaces and colloids, 25(14), 8200-8207 (2009-05-13)
We visualized nanometer-scale phospholipid particle fusion by scanning tunneling microscopy (STM) on an alkanethiol-modified gold substrate, induced by duramycin, a tetracyclic antibiotic peptide with 19 amino residues. Ultrasonic homogenization generated a suspension mainly consisting of minimal lipid particles (MLP) from
Andrei Marconescu et al.
Biochimica et biophysica acta, 1778(10), 2217-2224 (2008-06-24)
The major anionic phospholipid, phosphatidylserine (PS), and the neutral phospholipid, phosphatidylethanolamine (PE), are largely confined to the inner leaflet of the plasma membrane bilayer in mammalian cells under normal conditions. This asymmetry is lost when cells undergo apoptosis, become activated
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