C1112

CP-55940

>98% (HPLC), powder

• Synonym(e): 5-(1,1-Dimethylheptyl)-2-[5-hydroxy-2-(3-hydroxypropyl)cyclohexyl]phenol
• Empirische Formel (Hill-System): C₂₄H₄₀O₃
• CAS-Nummer: 83002-04-4
• Molekulargewicht: 376.57
• MDL-Nummer: MFCD00673965
• UNSPSC-Code: 12352200
• PubChem Substanz-ID: 24278295
• NACRES: NA.77

Eigenschaften

• Qualitätsniveau: 100
• Assay: >98% (HPLC)
• Form: powder
• Optische Aktivität: [α]/D -24 to -30°, c = 0.2 in chloroform-d
• Arzneimittelkontrolle: regulated under CDSA - not available from Sigma-Aldrich Canada
• Lagerbedingungen: desiccated
• Löslichkeit: DMSO: 15 mg/mL; H₂O: slightly soluble
• Lagertemp.: 2-8°C
• SMILES String: CCCCCCC(C)(C)c1ccc([C@@H]2C[C@H](O)CC[C@H]2CCCO)c(O)c1
• InChI: 1S/C24H40O3/c1-4-5-6-7-14-24(2,3)19-11-13-21(23(27)16-19)22-17-20(26)12-10-18(22)9-8-15-25/h11,13,16,18,20,22,25-27H,4-10,12,14-15,17H2,1-3H3/t18-,20-,22-/m1/s1
• InChIKey: YNZFFALZMRAPHQ-SYYKKAFVSA-N
• Angaben zum Gen: human ... CNR1(1268) , CNR2(1269) ; rat ... Cnr1(25248)

Beschreibung

Anwendung

CP-55940 has been used as a cannabinoid agonists in Chinese hamster ovary (CHO) expressing cannabinoid receptor 2(CB2).

Biochem./physiol. Wirkung

CP-55940 is a nonclassical cannabinoids (NCCs), which lack the tetrahydropyran ring. CP-55940, a derivative of CP-47,497 is enantioselective. Due to its amphipathic nature, CP-55940 tethers in biological membrane making it favourable for the cannabinoid receptor interaction. CP-55940 belongs to the cyclohexylphenol category and modulates the brain lipidome leading to dysregulation especially during adolescence. It inhibits capsaicin-evoked sensitization of nociceptive and spinal dorsal horn neurons.

CP-55940 is a selective cannabinoid receptor agonist.

Leistungsmerkmale und Vorteile

This compound is featured on the Cannabinoid Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Sicherheitshinweise

• Piktogramme: GHS07
• Signalwort: Warning
• H-Sätze: H336
• P-Sätze: P261 - P271 - P304 + P340 + P312 - P403 + P233 - P405 - P501
• Gefahreneinstufungen: STOT SE 3
• Zielorgane: Respiratory system
• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• Persönliche Schutzausrüstung: Eyeshields, Gloves, type N95 (US)