A5835

4-Aminobutansäure

≥99%, suitable for ligand binding assays, BioXtra

• Synonym(e): γ-Aminobuttersäure, 3-Carboxypropylamin, GABA, Piperidinsäure
• Lineare Formel: NH₂(CH₂)₃COOH
• CAS-Nummer: 56-12-2
• Molekulargewicht: 103.12
• Beilstein: 906818
• EG-Nummer: 200-258-6
• MDL-Nummer: MFCD00008226
• UNSPSC-Code: 12352106
• PubChem Substanz-ID: 24891025
• NACRES: NA.26

Eigenschaften

• Produktbezeichnung: 4-Aminobutansäure, BioXtra, ≥99%
• Produktlinie: BioXtra
• Qualitätsniveau: 200
• Assay: ≥99%
• Form: powder
• Methode(n): ligand binding assay: suitable
• Verunreinigungen: <0.0005% Phosphorus (P); <0.1% Insoluble matter
• Glührückstand: <0.1%
• Farbe: white
• mp (Schmelzpunkt): 195 °C (dec.) (lit.)
• Löslichkeit: H₂O: 0.5 M at 20 °C, clear, colorless
• Anionenspuren: chloride (Cl^-): <0.04%; sulfate (SO₄^2-): <0.05%
• Kationenspuren: Al: <5 mg/kg; Ca: <20 mg/kg; Cu: <5 mg/kg; Fe: <5 mg/kg; K: <50 mg/kg; Mg: <50 mg/kg; NH₄⁺: <500 mg/kg; Na: <70 mg/kg; Pb: <10 mg/kg; Zn: <5 mg/kg
• SMILES String: NCCCC(O)=O
• InChI: 1S/C4H9NO2/c5-3-1-2-4(6)7/h1-3,5H2,(H,6,7)
• InChIKey: BTCSSZJGUNDROE-UHFFFAOYSA-N
• Angaben zum Gen: human ... SLC6A1(6529) , SLC6A11(6538) , SLC6A12(6539) ; rat ... Gabra1(29705) , Gabra2(29706) , Olr1750(294204) , Slc6a1(79212) , Slc6a12(50676)

Beschreibung

Allgemeine Beschreibung

γ-Aminobutyric acid (GABA) is a non-protein amino acid associated with the brain. Being synthesized in the nervous system, it is packed into synaptic vesicles. It is present naturally in green tea, soybean, germinated rice, and in some fermented foods.

Anwendung

γ-Aminobutyric acid (GABA) has been used to treat dorsal root ganglion neurons for electrophysiological recordings studies to test its effect on neuropathic pain in rats. It has also been used to test its protective effects in an ex vivo machine perfusion system of small-for-size grafts (SFSG) injury model.

Biochem./physiol. Wirkung

Wichtigster hemmender Neurotransmitter im Gehirn; GABA_A und GABA_B Rezeptor Agonist; erhöht Leitfähigkeit für Cl⁻.

γ-Aminobutyric acid (GABA) is a mammalian inhibitory neurotransmitter with multiple functions. It is crucial for the normal central nervous system (CNS) functioning. A few documented functions of GABA include its protective role in toxin-induced damage. It also elicits anti-hypertensive, anti-diabetic, anti-microbial, antioxidant, anti-allergy, anti-inflammatory, and anti-cancer effects. GABA might show beneficial effects on stress and sleep in humans. γ-Aminobutyric acid (GABA) is used to study the biological and biochemical processes mediated via the GABA receptors, GABAA and GABAB.

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 1
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• Persönliche Schutzausrüstung: dust mask type N95 (US), Eyeshields, Gloves