A3734

1-Azakenpaullone

≥97% (HPLC)

• Synonym(e): 9-Bromo-7,12-dihydro-pyrido[3′,2′:2,3]azepino[4,5-b]indol-6(5H)-one
• Empirische Formel (Hill-System): C₁₅H₁₀BrN₃O
• CAS-Nummer: 676596-65-9
• Molekulargewicht: 328.16
• MDL-Nummer: MFCD09037522
• UNSPSC-Code: 12352200
• PubChem Substanz-ID: 329770845
• NACRES: NA.77

Eigenschaften

• Qualitätsniveau: 100
• Assay: ≥97% (HPLC)
• Form: powder
• Lagerbedingungen: protect from light
• Farbe: gray-brown
• Löslichkeit: DMSO: >10 mg/mL
• Lagertemp.: 2-8°C
• SMILES String: O=C1CC2=C(NC3=C2C=C(Br)C=C3)C4=C(C=CC=N4)N1
• InChI: 1S/C15H10BrN3O/c16-8-3-4-11-9(6-8)10-7-13(20)18-12-2-1-5-17-15(12)14(10)19-11/h1-6,19H,7H2,(H,18,20)
• InChIKey: NTSBZVCEIVPKBJ-UHFFFAOYSA-N

Beschreibung

Biochem./physiol. Wirkung

1-Azakenpaullone (AZP) can stimulate the transcription of β-catenin-related genes. This compound can induce the multiplication and replication of β cell.

1-Azakenpaullone is a cell permeable, potent, selective inhibitor of glycogen synthase kinase 3β (GSK3β) with 100-fold less cross-reactivity against CDKs.

1-Azakenpaullone is a cell permeable, potent, selective inhibitor of glycogen synthase kinase 3β (GSK3β) with 100-fold less cross-reactivity against CDKs. 1-Azakenpaullone can be used together with BIO and CHIR99021 as "gold standards" for GSK3 inhibition.

Vorsicht

air sensitive

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 2
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable