A2861

Astemizol

≥98% (HPLC)

• Synonym(e): 1-(4-Fluorbenzyl)-N-{1-[2-(4-methoxyphenyl)-ethyl]-4-piperidyl}-1H-benzimidazol-2-ylamin
• Empirische Formel (Hill-System): C₂₈H₃₁FN₄O
• CAS-Nummer: 68844-77-9
• Molekulargewicht: 458.57
• EG-Nummer: 272-441-9
• MDL-Nummer: MFCD00153919
• UNSPSC-Code: 41121800
• PubChem Substanz-ID: 329770802
• NACRES: NA.77

Eigenschaften

• Qualitätsniveau: 100
• Assay: ≥98% (HPLC)
• Form: powder
• Lagerbedingungen: desiccated; protect from light
• Löslichkeit: DMSO: >20 mg/mL
• Ersteller: Johnson & Johnson
• Lagertemp.: 2-8°C
• SMILES String: COc1ccc(CCN2CCC(CC2)Nc3nc4ccccc4n3Cc5ccc(F)cc5)cc1
• InChI: 1S/C28H31FN4O/c1-34-25-12-8-21(9-13-25)14-17-32-18-15-24(16-19-32)30-28-31-26-4-2-3-5-27(26)33(28)20-22-6-10-23(29)11-7-22/h2-13,24H,14-20H2,1H3,(H,30,31)
• InChIKey: GXDALQBWZGODGZ-UHFFFAOYSA-N
• Angaben zum Gen: human ... HRH1(3269)

Beschreibung

Biochem./physiol. Wirkung

Astermizole is a potent hERG potassium channel blocker (IC₅₀ of 0.9 nM) and may used as a pharmacological chaperone to correct folding defects and restore protein function for some mutated forms of hERG channels. It has also been studied for treatment of malaria, hERG and hEAG channel function in cancer and as a second generation antihistamine H-1 antagonist.

Leistungsmerkmale und Vorteile

This compound is featured on the Potassium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Johnson & Johnson. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Sicherheitshinweise

• Piktogramme: GHS07
• Signalwort: Warning
• H-Sätze: H315,H319,H335
• P-Sätze: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Gefahreneinstufungen: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Zielorgane: Respiratory system
• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable