T6764

Triprolidin -hydrochlorid

≥99%

• Synonym(e): (E)-2-[3-(1-Pyrrolidinyl)-1-p-tolylpropenyl]pyridine hydrochloride, trans-2-[3-(1-Pyrrolidinyl)-1-p-tolylpropenyl]pyridine hydrochloride
• Empirische Formel (Hill-System): C₁₉H₂₂N₂ · HCl
• CAS-Nummer: 6138-79-0
• Molekulargewicht: 314.85
• MDL-Nummer: MFCD00039044
• UNSPSC-Code: 12352200
• PubChem Substanz-ID: 24277808
• NACRES: NA.77

Eigenschaften

• Qualitätsniveau: 200
• Assay: ≥99%
• Löslichkeit: alcohol: soluble 1 in 1.5 of solvent; chloroform: soluble 1 in less than 1 of solvent; H₂O: soluble 50 mg/mL, clear, colorless to yellow
• Ersteller: GlaxoSmithKline
• Lagertemp.: 2-8°C
• SMILES String: CC(C=C1)=CC=C1/C(C2=NC=CC=C2)=C\CN3CCCC3.Cl
• InChI: 1S/C19H22N2.ClH/c1-16-7-9-17(10-8-16)18(19-6-2-3-12-20-19)11-15-21-13-4-5-14-21;/h2-3,6-12H,4-5,13-15H2,1H3;1H/b18-11+;
• InChIKey: WYUYEJNGHIOFOC-NWBUNABESA-N
• Angaben zum Gen: human ... HRH1(3269)

Beschreibung

Anwendung

Triprolidine has been used as a H1 histaminergic inhibitor to study its effect on long-term potentiation (LTP) in tuberomammillary nucleus (TMN) neurons.

Biochem./physiol. Wirkung

H₁ histamine receptor antagonist.

Leistungsmerkmale und Vorteile

This compound is featured on the Histamine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by GlaxoSmithKline. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Angaben zur Herstellung

Triprolidine hydrochloride is soluble in water at 50 mg/ml and yields a clear, colorless to yellow solution. It is also soluble in alcohol (1 in 1.5 of solvent) and chloroform (1 in less than 1 of solvent).

Sicherheitshinweise

• Piktogramme: GHS07
• Signalwort: Warning
• H-Sätze: H302,H315,H319,H335
• P-Sätze: P261 - P264 - P271 - P301 + P312 - P302 + P352 - P305 + P351 + P338
• Gefahreneinstufungen: Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Zielorgane: Respiratory system
• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Persönliche Schutzausrüstung: dust mask type N95 (US), Eyeshields, Gloves