A2487

Cotrimoxazole, Ready Made Solution

100 mg/mL in DMSO

• Synonym(e): Trimethoprim-Sulfamethoxazole, TMP-SMX
• Empirische Formel (Hill-System): C₁₄H₁₈N₄O₃ · 5 C₁₀H₁₁N₃O₃S
• CAS-Nummer: 8064-90-2
• Molekulargewicht: 1556.71
• MDL-Nummer: MFCD00242808
• UNSPSC-Code: 51102829
• NACRES: NA.85

Eigenschaften

• Form: liquid
• Qualitätsniveau: 200
• Konzentration: 100 mg/mL in DMSO
• Farbe: colorless to faint yellow
• Wirkungsspektrum von Antibiotika: Gram-negative bacteria; Gram-positive bacteria; fungi; parasites
• Wirkungsweise: DNA synthesis | interferes
• Versandbedingung: dry ice
• Lagertemp.: −20°C
• SMILES String: [S](=O)(=O)(Nc4n[o]c(c4)C)c3ccc(cc3)N.Nc1nc(c(cn1)Cc2cc(c(c(c2)OC)OC)OC)N
• InChI: 1S/C14H18N4O3.C10H11N3O3S/c1-19-10-5-8(6-11(20-2)12(10)21-3)4-9-7-17-14(16)18-13(9)15;1-7-6-10(12-16-7)13-17(14,15)9-4-2-8(11)3-5-9/h5-7H,4H2,1-3H3,(H4,15,16,17,18);2-6H,11H2,1H3,(H,12,13)
• InChIKey: WZRJTRPJURQBRM-UHFFFAOYSA-N

Beschreibung

Anwendung

Cotrimoxazole has been used as an antimicrobial agent.

Biochem./physiol. Wirkung

Cotrimoxazole, a combination of trimethoprim and sulfamethoxazole, interferes with the cellular metabolism of folic acid in the bacterial cell by blocking the biosynthesis of nucleotides. Trimethoprim binds to dihydrofolate reductase (DHFR) which inhibits the reduction of dihydrofolic acid (DHF) to tetrahydrofolic acid (THF), resulting in an antimicrobial effect. Sulfamethoxazole interferes with the synthesis of nucleic acids in sensitive microorganisms by blocking the conversion of p-aminobenzoic acid to the coenzyme dihydrofolic acid. The net effect of these actions is to inhibit thymidine synthesis which prevents bacterial DNA synthesis.

Verpackung

1ml

Angaben zur Herstellung

prepared using a 1:5 mixture of trimethoprim:sulfamethoxazole

Sonstige Hinweise

Keep container tightly closed in a dry and well-ventilated place.

Sicherheitshinweise

• Piktogramme: GHS08
• Signalwort: Warning
• H-Sätze: H361fd,H412
• P-Sätze: P202 - P273 - P280 - P308 + P313 - P405 - P501
• Gefahreneinstufungen: Aquatic Chronic 3 - Repr. 2
• Lagerklassenschlüssel: 12 - Non Combustible Liquids
• WGK: WGK 2
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable