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Merck

A1164

Sigma-Aldrich

Azaserin

Hybri-Max, γ-irradiated, 50x, lyophilized powder, BioXtra, suitable for hybridoma

Synonym(e):

O-Diazoacetyl-L-serin

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About This Item

Empirische Formel (Hill-System):
C5H7N3O4
CAS-Nummer:
Molekulargewicht:
173.13
Beilstein:
1726602
EG-Nummer:
MDL-Nummer:
UNSPSC-Code:
12352207
PubChem Substanz-ID:
NACRES:
NA.75

Qualität

Hybri-Max

Qualitätsniveau

Sterilität

γ-irradiated

Produktlinie

BioXtra

Form

lyophilized powder

Methode(n)

cell culture | hybridoma: suitable

Verunreinigungen

endotoxin, tested

Wirkungsspektrum von Antibiotika

fungi

Wirkungsweise

enzyme | inhibits

Lagertemp.

−20°C

SMILES String

N[C@@H](COC(=O)C=[N+]=[N-])C(O)=O

InChI

1S/C5H7N3O4/c6-3(5(10)11)2-12-4(9)1-8-7/h1,3H,2,6H2,(H,10,11)/t3-/m0/s1

InChIKey

MZZGOOYMKKIOOX-VKHMYHEASA-N

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Allgemeine Beschreibung

Chemical structure: amino acid derivatives

Anwendung

For use in hybridoma cell culture applications as a myeloma selection agent. Used to study inhibition of formylglycinamide ribonucleotide amidotransferase and PRPP amidotransferase.

Biochem./physiol. Wirkung

Azaserine is an antibiotic, generated by Streptomyces fragilis. It is considered as a potential mutation inducing agent. It is known to promote pancreatic cancer and induces adenoma and carcinoma in vivo and in vitro. Azaserine also stimulates kidney and liver tumors in rats.

Rekonstituierung

Reconstitute contents of vial with 10 mL sterile cell culture medium. Stock solution is sufficient to prepare 500 mL medium. Final working concentration: 5.7 μM azaserine.

Rechtliche Hinweise

Hybri-Max is a trademark of Sigma-Aldrich Co. LLC

Piktogramme

Skull and crossbonesHealth hazard

Signalwort

Danger

H-Sätze

Gefahreneinstufungen

Acute Tox. 3 Oral - Carc. 2

Lagerklassenschlüssel

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Persönliche Schutzausrüstung

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges


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The American journal of pathology, 165(6), 2135-2145 (2004-12-08)
The presence of gastrin and cholecystokinin-2 (CCK2) receptors in human preneoplastic and neoplastic gastrointestinal lesions suggests a role in cancer development. In addition to the growth-promoting action of gastrin, recently a role of the cholecystokinin-2/gastrin receptor (CCK2-R) modulating cellular morphology
Songon An et al.
Science (New York, N.Y.), 320(5872), 103-106 (2008-04-05)
Purines are synthesized de novo in 10 chemical steps that are catalyzed by six enzymes in eukaryotes. Studies in vitro have provided little evidence of anticipated protein-protein interactions that would enable substrate channeling and regulation of the metabolic flux. We
Marie Pantaleon et al.
Biology of reproduction, 78(4), 595-600 (2007-11-30)
Although mouse oocytes and cleavage-stage embryos are unable to utilize glucose as a metabolic fuel, they have a specific requirement for a short exposure to glucose prior to compaction. The reason for this requirement has been unclear. In this study

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