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A0887

Sigma-Aldrich

5α-Androstane

Synonym(e):

Etioallocholane

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About This Item

Empirische Formel (Hill-System):
C19H32
CAS-Nummer:
438-22-2
Molekulargewicht:
260.46
EG-Nummer:
207-116-2
MDL-Nummer:
MFCD00067600
UNSPSC-Code:
12352211
PubChem Substanz-ID:
24890466
NACRES:
NA.77

Assay

≥99% (HPLC)

Qualitätsniveau

200

Form

powder

Löslichkeit

chloroform: 49-51 mg/mL, clear, colorless

Versandbedingung

ambient

Lagertemp.

room temp

SMILES String

[H][C@@]12CC[C@@]3([H])CCCC[C@]3(C)[C@@]1([H])CC[C@]4(C)CCC[C@@]24[H]

InChI

1S/C19H32/c1-18-11-5-7-16(18)15-9-8-14-6-3-4-12-19(14,2)17(15)10-13-18/h14-17H,3-13H2,1-2H3/t14-,15+,16+,17+,18+,19+/m1/s1

InChIKey

QZLYKIGBANMMBK-UGCZWRCOSA-N

Angaben zum Gen

human ... UGT1A4(54657)

Anwendung

5α-Androstane has been used to treat androgen-dependent and androgen-independent prostate cancer cells (LNCaP and PC-3) to investigate cell proliferation, viability, adhesion and hormone expression.

Sonstige Hinweise

Serves as the parent steroid skeleton for all androgens, but the hydrocarbon itself is not naturally occurring.

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Persönliche Schutzausrüstung

Eyeshields, Gloves, type N95 (US)

Analysenzertifikate (COA)

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5α-Androstan-17β-ol-3-on purum, ≥99.0% (TLC)

Sigma-Aldrich

10300

5α-Androstan-17β-ol-3-on

C8-C40-Alkane-Kalibrierstandard in dichloromethane (varied)

Supelco

40147-U

C8-C40-Alkane-Kalibrierstandard

Testosteronpropionat solid

Sigma-Aldrich

T1875

Testosteronpropionat

Haodong Ji et al.
Marine pollution bulletin, 135, 427-440 (2018-10-12)
Oil degradation by surface-level atmospheric ozone has been largely ignored in the field. To address this knowledge gap, this study investigated the ozonation rate and extent of typical petroleum compounds by simulated surface-level ozone, including total petroleum hydrocarbons (TPHs), n-alkanes
Estrogen and androgen hormone levels modulate the expression of PIWI interacting RNA in prostate and breast cancer
Oner C, et al.
PLoS ONE, 11(7), e0159044-e0159044 (2016)
Nathan J Cherrington et al.
The Journal of pharmacology and experimental therapeutics, 300(1), 97-104 (2001-12-26)
Many phase I and II microsomal enzyme inducers share common mechanisms of transcriptional activation and thus share a similar battery of genes that are coordinately regulated. Many phase II metabolites are thought to be transported out of cells by multidrug
Claudia Cimpoiu et al.
Journal of pharmaceutical and biomedical analysis, 41(2), 633-637 (2006-01-24)
The aim of this paper was the analysis of five androstane isomers by thin-layer chromatography (TLC). The choice of proper mobile phase and the optimization of the mobile phase composition are very important because the chromatographic separation is difficult to
Kaoru Kobayashi et al.
Drug metabolism and disposition: the biological fate of chemicals, 33(7), 924-929 (2005-04-02)
Constitutive active (or androstane) receptor (CAR, NR1I3), a member of the nuclear receptor family, is a major regulator for induction of cytochrome P450 2B (CYP2B) genes by phenobarbital. Phenobarbital-like inducer, 1,4-bis[2-(3,5-dichloropyridyloxy)]benzene is a potent mouse CAR ligand that has been
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