17946

1α-Hydroxy-vitamin D₃

≥97.0% (HPLC)

• Synonym(e): 1α-Hydroxy-cholecalciferol, Alfacalcidol
• Empirische Formel (Hill-System): C₂₇H₄₄O₂
• CAS-Nummer: 41294-56-8
• Molekulargewicht: 400.64
• EG-Nummer: 255-297-1
• MDL-Nummer: MFCD00868328
• UNSPSC-Code: 12352205
• PubChem Substanz-ID: 57647693
• NACRES: NA.79

Eigenschaften

• Biologische Quelle: synthetic
• Qualitätsniveau: 200
• Assay: ≥97.0% (HPLC)
• Form: powder or crystals
• Farbe: white to off-white
• Lagertemp.: −20°C
• SMILES String: CC(C)CCC[C@@H](C)[C@H]1CC[C@H]2\C(CCC[C@]12C)=C\C=C3\C[C@@H](O)C[C@H](O)C3=C
• InChI: 1S/C27H44O2/c1-18(2)8-6-9-19(3)24-13-14-25-21(10-7-15-27(24,25)5)11-12-22-16-23(28)17-26(29)20(22)4/h11-12,18-19,23-26,28-29H,4,6-10,13-17H2,1-3,5H3/b21-11+,22-12-/t19-,23-,24-,25+,26+,27-/m1/s1
• InChIKey: OFHCOWSQAMBJIW-AVJTYSNKSA-N
• Angaben zum Gen: human ... VDR(7421)

Beschreibung

Allgemeine Beschreibung

1α-Hydroxyvitamin D₃, also known as alfacalcidol, is a synthetic vitamin D₃ analogue, hydroxylated in position one. It is metabolized to 1,25-dihydroxycholecalciferol by 25-hydroxylases.

Biochem./physiol. Wirkung

1α-Hydroxyvitamin D₃ facilitates calcium absorption and deposition. It also has an ability to inhibit bone resorption and stimulate bone formation. Alfacalcidol is used for treating various bone diseases such as rickets/osteomalacia, renal osteodystrophy and osteoporosis. It acts as a chemopreventive agent and reduces the risk colitis and carcinogenesis.

Synthetisches Vitamin D₃-Aanalogon, das zu 1,25-Dihydroxycholecalciferol verstoffwechselt wird. Hemmt die Knochenresorption und stimuliert die Knochenbildung. Unterdrückt Parathormon-Sekretion durch Rindemebenschilddrüsenzellen.

Verpackung

Bottomless glass bottle. Contents are inside inserted fused cone.

Sicherheitshinweise

• Piktogramme: GHS06
• Signalwort: Danger
• H-Sätze: H300
• P-Sätze: P301 + P330 + P331 + P310
• Gefahreneinstufungen: Acute Tox. 1 Oral
• Lagerklassenschlüssel: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• Persönliche Schutzausrüstung: Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges