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N-Dodecanoyl-DL-homoserin-lacton
≥97.0% (HPLC), suitable for ligand binding assays
Synonym(e):
N-Lauroyl-DL-homoserin-lacton
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About This Item
Empirische Formel (Hill-System):
C16H29NO3
CAS-Nummer:
Molekulargewicht:
283.41
MDL-Nummer:
UNSPSC-Code:
12352209
eCl@ss:
32160406
PubChem Substanz-ID:
NACRES:
NA.26
Empfohlene Produkte
product name
N-Dodecanoyl-DL-homoserin-lacton, ≥97.0% (HPLC)
Qualitätsniveau
Assay
≥97.0% (HPLC)
Form
powder
Methode(n)
ligand binding assay: suitable
Farbe
white to faint beige
mp (Schmelzpunkt)
114-117 °C
Lagertemp.
2-8°C
SMILES String
CCCCCCCCCCCC(=O)NC1CCOC1=O
InChI
1S/C16H29NO3/c1-2-3-4-5-6-7-8-9-10-11-15(18)17-14-12-13-20-16(14)19/h14H,2-13H2,1H3,(H,17,18)
InChIKey
WILLZMOKUUPJSL-UHFFFAOYSA-N
Verwandte Kategorien
Anwendung
Anwendungstest: Induziert Violaceinexpression in einem Chromobacterium violaceum Mutanten, der normalerweise keine Homoserinlaktone produzieren kann. .
Biochem./physiol. Wirkung
N-Dodecanoyl-DL-homoserine lactone (C12-HSL) is among a group of homoserine lactones that includes; N-Heptanoyl-DL-homoserine lactone (C7HSL), N-octanoyl-homoserine lactone (N-C8-HSL), N-Decanoyl-DL-homoserine lactone (N-C10-HSL), N-(3-oxodecanoyl) homoserine-L-lactone (3-oxo-C10 HSL), N-(3-oxododecanoyl)homoserine-L-lactone (3-oxo-C12-HSL), N-(3-Oxotetradecanoyl)-L-homoserine lactone (3-oxo-C14-HSL, N-(3-hydroxydecanoyl)-L-homoserine lactone, and N-(3-hydroxyoctanoyl)-L-homoserine lactone involved in the processes of bacterial quorum sensing. These N-acyl-homoserine lactones are used to study the processes and mechanisms of bacterial quorum sensing.
N-Lauroyl- DL-homoserine lactone is a member of N-acyl-homoserine lactone family. N-acylhomoserine lactones (AHL) regulate gene expression in gram-negative bacteria, such as Echerichia and Salmonella are involved in quorum sensing, cell to cell communication among bacteria. Some AHLs are potent chemoattractants for human immune cells such as neutrophils.
Quorum-sensing signal generation.
Verpackung
Bottomless glass bottle. Contents are inside inserted fused cone.
Lagerklassenschlüssel
11 - Combustible Solids
WGK
WGK 3
Flammpunkt (°F)
Not applicable
Flammpunkt (°C)
Not applicable
Persönliche Schutzausrüstung
Eyeshields, Gloves, type N95 (US)
Analysenzertifikate (COA)
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Sophie Uzureau et al.
Journal of proteome research, 9(6), 3200-3217 (2010-04-15)
Many pathogenic bacteria use a regulatory process termed quorum sensing (QS) to produce and detect small diffusible molecules to synchronize gene expression within a population. In Gram-negative bacteria, the detection of, and response to, these molecules depends on transcriptional regulators
Deisy G Carneiro et al.
Frontiers in microbiology, 11, 1459-1459 (2020-08-28)
Acyl-homoserine lactones (AHLs) are quorum sensing (QS) signaling molecules that mediate cell-to-cell communication in Gram-negative bacteria. Salmonella does not produce AHL, however, it can recognize AHLs produced by other species through SdiA protein modulating important cellular functions. In this work
Kazunori Gomi et al.
Infection and immunity, 74(12), 7029-7031 (2006-09-20)
Chromobacterium violaceum produces autoinducers, including homoserine lactones (HSLs), for genetic regulation. Among the seven HSLs derived from C. violaceum we evaluated, only C(12)-HSL stimulated the production of inflammatory cytokines in mammalian monocytic cell lines through the activation of the NF-kappaB
Daniel Wynn et al.
The Analyst, 143(19), 4774-4782 (2018-09-15)
There are an estimated 48 million cases of foodborne illness in the United States every year. In general, these illnesses are the result of unintentional contamination and improper food handling. Because bacterial contamination plays a major role in food spoilage
Miriam Khider et al.
PeerJ, 7, e6845-e6845 (2019-05-21)
Bacterial communication through quorum sensing (QS) systems has been reported to be important in coordinating several traits such as biofilm formation. In Aliivibrio salmonicida two QS systems the LuxI/R and AinS/R, have been shown to be responsible for the production
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