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Y0001400

Vigabatrin

European Pharmacopoeia (EP) Reference Standard

Synonym(e):

(±)-Vigabatrin, (R,S)-4-Amino-5-hexenoic acid, (±)-γ-Vinyl-GABA, (±)-4-Aminohexenoic acid

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About This Item

Empirische Formel (Hill-System):
C6H11NO2
CAS-Nummer:
68506-86-5
Molekulargewicht:
129.16
MDL-Nummer:
MFCD00274577
UNSPSC-Code:
41116107
PubChem Substanz-ID:
329831404
NACRES:
NA.24

Qualität

pharmaceutical primary standard

API-Familie

vigabatrin

Hersteller/Markenname

EDQM

Anwendung(en)

pharmaceutical (small molecule)

Format

neat

Lagertemp.

2-8°C

SMILES String

NC(CCC(O)=O)C=C

InChI

1S/C6H11NO2/c1-2-5(7)3-4-6(8)9/h2,5H,1,3-4,7H2,(H,8,9)

InChIKey

PJDFLNIOAUIZSL-UHFFFAOYSA-N

Angaben zum Gen

human ... ABAT(18)

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Allgemeine Beschreibung

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Anwendung

Vigabatrin EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Biochem./physiol. Wirkung

Irreversible GABA transaminase inhibitor. Increases intracellular concentration of GABA in nerve endings; possesses antiepileptic activity.

Verpackung

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Sonstige Hinweise

Sales restrictions may apply.

Piktogramme

Health hazard
GHS08

Signalwort

Danger

H-Sätze

H372

Gefahreneinstufungen

STOT RE 1

Zielorgane

Eyes,Central nervous system

Lagerklassenschlüssel

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 1

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

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Analysenzertifikate (COA)

Lot/Batch Number

Leider sind derzeit keine COAs für dieses Produkt online verfügbar.

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Die Dokumentenbibliothek aufrufen

Vigabatrin-associated visual field loss.
Chris Fecarotta et al.
International ophthalmology clinics, 52(3), 87-94 (2012-06-07)
E Ben-Menachem et al.
Acta neurologica Scandinavica. Supplementum, (192)(192), 16-28 (2011-11-09)
Complex partial seizures (CPS) are a form of localization-related seizures associated with serious comorbidities and risks. CPS can be difficult to treat and may remain refractory to treatment with antiepileptic drugs (AEDs). Refractory CPS (rCPS) can be hazardous because of
Robert C Sergott
Current opinion in ophthalmology, 21(6), 442-446 (2010-09-03)
Although vigabatrin has been used for many years in Europe, this antiepileptic medication was approved for use in the USA only 1 year ago because of concerns for irreversible peripheral visual field loss that can result in functional visual disability.
Harinder Jaseja
Clinical neurology and neurosurgery, 111(2), 111-114 (2008-10-11)
West syndrome (WS) or infantile spasms (IS) is a severe epileptic syndrome associated with poor prognosis and increased morbidity. The exact etio-pathogenesis of the disorder still remains elusive ant therefore the management continues to pose a challenge to the clinicians.
R C Sergott et al.
Acta neurologica Scandinavica. Supplementum, (192)(192), 48-56 (2011-11-09)
Vigabatrin, an irreversible inhibitor of γ-aminobutyric acid transaminase, is an antiepileptic drug indicated in the United States as adjunctive therapy for adult patients with refractory complex partial seizures who have responded inadequately to several alternative treatments and for monotherapy treatment
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