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Wichtige Dokumente
F0175000
Flucytosin
European Pharmacopoeia (EP) Reference Standard
Synonym(e):
5-Fluorcytosin, 4-Amino-5-fluor-2-hydroxy-pyrimidin, Flucytosin
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About This Item
Empirische Formel (Hill-System):
C4H4FN3O
CAS-Nummer:
Molekulargewicht:
129.09
Beilstein:
127285
MDL-Nummer:
UNSPSC-Code:
41116107
PubChem Substanz-ID:
NACRES:
NA.24
Empfohlene Produkte
Qualität
pharmaceutical primary standard
API-Familie
flucytosine
Hersteller/Markenname
EDQM
mp (Schmelzpunkt)
298-300 °C (dec.) (lit.)
Anwendung(en)
pharmaceutical (small molecule)
Format
neat
Lagertemp.
2-8°C
SMILES String
NC1=NC(=O)NC=C1F
InChI
1S/C4H4FN3O/c5-2-1-7-4(9)8-3(2)6/h1H,(H3,6,7,8,9)
InChIKey
XRECTZIEBJDKEO-UHFFFAOYSA-N
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Allgemeine Beschreibung
This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.
Anwendung
Flucytosine EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.
Biochem./physiol. Wirkung
Nukleosid-Analogon mit antimykotischen Aktivitäten. 5-FC wird durch Cytosindeaminase zu 5-Fluoruracil deaminiert, was zur RNA Fehlcodierung führt. 5-Fluorcytosin hemmt die DNA- und RNA-Synthese und stört die ribosomale Proteinsynthese.
Verpackung
Dieses Produkt wird, wie von der entsprechenden Pharmakopöe geliefert, angeboten. Die aktuellen Mengeneinheiten finden Sie im Referenzsubstanzen-Katalog der EDQM.
Sonstige Hinweise
Sales restrictions may apply.
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Analysenzertifikate (COA)
Lot/Batch Number
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Bilateral fungal obstruction of the renal collecting system is rare in infancy. Treatment options include medical or surgical procedures. Reports of successful medical treatment with liposomal amphotericin B have been published but the duration of treatment is controversial. We report
A Polak
Annales de biologie clinique, 45(6), 669-672 (1987-01-01)
The antimycotic and pharmacological properties of 5-fluorocytosine are presented. Especially the aspect of good gastrointestinal absorption, elimination by the kidney, unwanted side effects and appearance of primary and secondary resistance are discussed. The indication of 5 FC monotherapy or combination
R Patel
Mayo Clinic proceedings, 73(12), 1205-1225 (1998-12-30)
Traditionally, amphotericin B has been the cornerstone of antifungal treatment. Toxicity, however, is a major dose-limiting factor of amphotericin B deoxycholate. Nevertheless, it continues to have a major role in the treatment of deep-seated mycotic infections. Recently, less nephrotic lipid
B Gerson
Clinics in laboratory medicine, 7(3), 541-544 (1987-09-01)
Monitoring of flucytosine (5-FC) concentration in serum is of great importance. It may be anticipated that demand for this service will increase in the near future, because this drug is used in situations involving immunocompromised patients, including those afflicted with
Angela Loyse et al.
The Journal of antimicrobial chemotherapy, 68(11), 2435-2444 (2013-06-22)
Current, widely accepted guidelines for the management of HIV-associated cryptococcal meningoencephalitis (CM) recommend amphotericin B combined with flucytosine (5-FC) for ≥2 weeks as the initial induction treatment of choice. However, access to flucytosine in Africa and Asia, where disease burden
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