C9774

Cholecalciferol

analytical standard

• Synonym(e): (+)-Vitamin D₃, 7-Dehydrocholesterol aktiviert, Aktiviertes 7-Dehydrocholesterin, Calciol
• Empirische Formel (Hill-System): C₂₇H₄₄O
• CAS-Nummer: 67-97-0
• Molekulargewicht: 384.64
• Beilstein: 2339331
• EG-Nummer: 200-673-2
• MDL-Nummer: MFCD00078131
• UNSPSC-Code: 12352205
• eCl@ss: 34058003
• PubChem Substanz-ID: 24893197
• NACRES: NA.77

Eigenschaften

• Biologische Quelle: synthetic (organic - wool)
• Qualitätsniveau: 200
• Qualität: analytical standard
• Assay: ≥97.0%
• Form: crystalline
• Verpackung: pkg of 250 mg
• Farbe: white
• mp (Schmelzpunkt): 83-86 °C (lit.)
• Lagertemp.: 2-8°C
• SMILES String: CC(C)CCC[C@@H](C)[C@@]1([H])CC[C@@]([C@]1(C)CCC/2)([H])C2=C\C=C(C[C@@H](O)CC3)/C3=C
• InChI: 1S/C27H44O/c1-19(2)8-6-9-21(4)25-15-16-26-22(10-7-17-27(25,26)5)12-13-23-18-24(28)14-11-20(23)3/h12-13,19,21,24-26,28H,3,6-11,14-18H2,1-2,4-5H3/b22-12+,23-13-/t21-,24+,25-,26+,27-/m1/s1
• InChIKey: QYSXJUFSXHHAJI-YRZJJWOYSA-N
• Angaben zum Gen: human ... VDR(7421)

Beschreibung

Allgemeine Beschreibung

Cholecalciferol, also called vitamin D₃, promotes the absorption of calcium and phosphorus in the body to regulate bone growth. It is most commonly found in humans and animals and is produced in our skin when exposed to sunlight. It is used to treat and prevent bone disorders (such as rickets, osteomalacia).

Anwendung

Cholecalciferol has been used as an internal standard in high-performance liquid chromatography (HPLC) to analyze serum vitamin D levels. It has also been used as a standard in liquid chromatography-electrospray ionization tandem mass spectrometry (LC-ESI-MS/MS) to quantify vitamin D3 in sunflower oil.

Cholecalciferol may be used as an analytical reference standard for the determination of the analyte in pharmaceutical formulations by liquid chromatography.

Biochem./physiol. Wirkung

Vitamin D agiert durch einen Rezeptor, der ein Mitglied der ligandenabhängigen Transkriptionsfaktor-Obergruppe ist. Es moduliert das Wachstum und die Differenzierung von normalen Zellen und Krebszellen. Hat wachstums- und Metastasenbildungs-hemmende Effekte auf Brust-, Dickdarm- und Prostatakrebszellen. Aktivierte Vitamin D-Rezeptoren in Darm- und Knochenzellen halten die Calciumabsorption und die Homöostasie aufrecht.

Cholecalciferol is sourced either through the diet or exposing skin to ultraviolet rays. Oral administration of vitamin D3 is readily absorbed and is stored in adipose tissue. Deficiency of vitamin D is often observed in chronic kidney disease.

Verpackung

Packaged in flame-sealed ampules under Argon

Sicherheitshinweise

• Piktogramme: GHS06,GHS08
• Signalwort: Danger
• H-Sätze: H300 + H310 + H330,H372
• P-Sätze: P260 - P262 - P280 - P302 + P352 + P310 - P304 + P340 + P310 - P314
• Gefahreneinstufungen: Acute Tox. 2 Dermal - Acute Tox. 2 Inhalation - Acute Tox. 2 Oral - STOT RE 1 Oral
• Lagerklassenschlüssel: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• WGK: WGK 2
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• Persönliche Schutzausrüstung: Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges