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Merck

41694

Supelco

5-Hydroxydiclofenac

analytical standard

Synonym(e):

2-[(2,6-Dichlor-phenyl)-amino]-5-hydroxy-benzolessigsäure

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About This Item

Empirische Formel (Hill-System):
C14H11Cl2NO3
CAS-Nummer:
Molekulargewicht:
312.15
Beilstein:
4199419
MDL-Nummer:
UNSPSC-Code:
41116107
PubChem Substanz-ID:
NACRES:
NA.24

Qualität

analytical standard

Qualitätsniveau

Assay

≥97.0% (HPLC)

Haltbarkeit

limited shelf life, expiry date on the label

Methode(n)

HPLC: suitable
gas chromatography (GC): suitable

Anwendung(en)

pharmaceutical

Format

neat

Lagertemp.

−20°C

SMILES String

OC(CC1=CC(O)=CC=C1NC2=C(Cl)C=CC=C2Cl)=O

InChI

1S/C14H11Cl2NO3/c15-10-2-1-3-11(16)14(10)17-12-5-4-9(18)6-8(12)7-13(19)20/h1-6,17-18H,7H2,(H,19,20)

InChIKey

VNQURRWYKFZKJZ-UHFFFAOYSA-N

Allgemeine Beschreibung

5-Hydroxydiclofenac, a monohydroxylated metabolite of diclofenac, belongs to the class of non-steroidal anti-inflammatory compounds.29}

Anwendung

5-Hydroxydiclofenac may be used as an analytical standard for the determination of the analyte in biological samples and wastewater by liquid chromatography (LC) based techniques.

Empfohlene Produkte

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Piktogramme

Exclamation markEnvironment

Signalwort

Warning

Gefahreneinstufungen

Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Zielorgane

Respiratory system

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable


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Die Dokumentenbibliothek aufrufen

Simultaneous determination of diclofenac, its human metabolites and microbial nitration/nitrosation transformation products in wastewaters by liquid chromatography/quadrupole-linear ion trap mass spectrometry
Osorio V, et al.
Journal of Chromatography A, 1347(1), 63-71 (2014)
High-performance liquid chromatographic method for the routine determination of diclofenac and its hydroxy and methoxy metabolites from in vitro systems
Schmitz G, et al.
Journal of Chromatography. B, Biomedical Applications, 620(1), 158-163 (1993)
Jing Shi et al.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 191, 1-7 (2017-10-02)
A novel flow injection chemiluminescence immunoassay for simple, sensitive and low-cost detection of diclofenac was established based on specific binding of antigen and antibody. Carboxylic resin beads used as solid phase carrier materials provided good biocompatibility and large surface-to-volume ratio
High-performance liquid chromatographic determination of diclofenac and its monohydroxylated metabolites in biological fluids
Godbillon J, et al.
Journal of Chromatography. B, Biomedical Applications, 338(1), 151-159 (1985)
Simon T K Yauw et al.
Surgical infections, 19(4), 417-423 (2018-04-07)
The non-steroidal anti-inflammatory drug diclofenac has been associated with intestinal anastomotic leakage, although the underlying pathophysiology is unclear. Previous data suggest that reactivation of biliary diclofenac metabolites by microbial β-glucuronidases in the gut plays a role in harming the intestinal

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