8.52347

Fmoc-Tyr(SO3nP)-OH

≥95.0% (HPLC), for peptide synthesis, Novabiochem^®

• Synonym(e): N-Fmoc-O-(2,2 dimethylpropylsulfo)-L-tyrosine
• Empirische Formel (Hill-System): C₂₉H₃₁NO₈S
• CAS-Nummer: 878408-63-0
• Molekulargewicht: 553.62
• UNSPSC-Code: 12352209
• NACRES: NA.22

Eigenschaften

• product name: Fmoc-Tyr(SO3nP)-OH, Novabiochem^®
• Qualitätsniveau: 200
• Produktlinie: Novabiochem^®
• Assay: ≥95.0% (HPLC)
• Form: powder
• Eignung der Reaktion: reaction type: Fmoc solid-phase peptide synthesis
• Hersteller/Markenname: Novabiochem^®
• Anwendung(en): peptide synthesis
• Funktionelle Gruppe: sulfonic acid
• Lagertemp.: -10 to -25°C

Beschreibung

Allgemeine Beschreibung

A novel derivative for the synthesis of sulfotyrosine-containing peptides by Fmoc SPPS. The sulfate neopentyl group is stable to TFA, and thus protects the sulfotyrosine residue from degradation during the cleavage reaction, but is easily cleaved post-cleavage by treatment of the peptide with aqueous ammonium acetate ^[1].

Associated Protocols and Technical Articles
Cleavage and Deprotection Protocols for Fmoc SPPS
Guide to Selection of Orthogonally -Protected Building Blocks for Fmoc SPPS

Literature references

^[1] L. S. Simpson & T. S. Widlanski (2006) J. Am. Chem. Soc., 128, 1605.
^[2] L. S. Simpson, et al. (2009) Chemistry & Biology, 16, 153.

Hinweis zur Analyse

Farbe (visuell): weiß bis schwach gelb bis beige
Aussehen der Substanz (visuell): Pulver
Identität (IR): entspricht
Enantiomerenreinheit: ≥ 99.0 % (a/a)
Reinheit (DC(BAW0)): ≥ 97 %
Gehalt (HPLC, Fl.%): ≥ 95.0 % (a/a)
Löslichkeit (1 mmol in 4 ml DMF): klar löslich
DC-Bedingungen gemäß den Angaben unseres Hauptkataloges

Rechtliche Hinweise

Novabiochem is a registered trademark of Merck KGaA, Darmstadt, Germany

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 2
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable