5.43899

NMP

for liquid chromatography LiChrosolv^®

• Synonym(e): NMP
• Empirische Formel (Hill-System): C₅H₉NO
• CAS-Nummer: 872-50-4
• Molekulargewicht: 99.13
• MDL-Nummer: MFCD00003193
• UNSPSC-Code: 41116105
• EG-Index-Nummer: 212-828-1
• NACRES: NA.03

Eigenschaften

• product name: 1-Methyl-2-pyrrolidone, for liquid chromatography LiChrosolv^®
• Dampfdruck: 0.32 hPa ( 20 °C)
• Qualitätsniveau: 100
• Produktlinie: LiChrosolv^®
• Qualität: isocratic
• Assay: ≥99.5% (GC)
• Form: liquid
• Selbstzündungstemp.: 245 °C
• Expl.-Gr.: 1.3-9.5 % (v/v)
• Methode(n): HPLC: suitable
• Verunreinigungen: ≤0.05% Water
• Durchlässigkeit: 300 nm, ≥50%; 325 nm, ≥90%; 350 nm, ≥97%; 400 nm, ≥99%
• pH-Wert: 8.5-10.0 (20 °C, 100 g/L in H₂O)
• bp: 202 °C/1013 hPa
• mp (Schmelzpunkt): -24 °C
• Übergangstemp.: flash point 91 °C
• Löslichkeit: 1000 g/L
• Dichte: 1.03 g/cm³ at 20 °C
• Lagertemp.: 2-30°C
• InChI: 1S/C5H9NO/c1-6-4-2-3-5(6)7/h2-4H2,1H3
• InChIKey: SECXISVLQFMRJM-UHFFFAOYSA-N

Beschreibung

Anwendung

• Novel transdermal bioadhesive surfactant-based system for release and solubility improvement of antimalarial drugs artemether-lumefantrine: This study utilizes 1-Methyl-2-pyrrolidone (NMP) as a high-purity solvent in the formulation of a transdermal bioadhesive system, enhancing the solubility and delivery of antimalarial drugs. The application highlights NMP′s role in pharmaceutical formulations, particularly in improving drug efficacy and patient compliance (Volpe-Zanutto et al., 2021).

Hinweis zur Analyse

Reinheit (GC): ≥ 99.5 %
Wasser: ≤ 0.05 %
Durchlässigkeit (bei 300 nm): ≥ 50 %
Durchlässigkeit (bei 325 nm): ≥ 90 %
Durchlässigkeit (bei 350 nm): ≥ 97 %
Durchlässigkeit (bei 400 nm): ≥ 99 %

Sonstige Hinweise

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Rechtliche Hinweise

LICHROSOLV is a registered trademark of Merck KGaA, Darmstadt, Germany

Sicherheitshinweise

• Piktogramme: GHS07,GHS08
• Signalwort: Danger
• H-Sätze: H315 - H319 - H335 - H360D
• P-Sätze: P202 - P261 - P264 - P302 + P352 - P305 + P351 + P338 - P308 + P313
• Gefahreneinstufungen: Eye Irrit. 2 - Repr. 1B - Skin Irrit. 2 - STOT SE 3
• Zielorgane: Respiratory system
• Lagerklassenschlüssel: 6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 1
• Flammpunkt (°F): 195.8 °F - Pensky-Martens closed cup
• Flammpunkt (°C): 91 °C - Pensky-Martens closed cup