218840

Caspase-8 Inhibitor II

InSolution

• Synonym(e): InSolution Caspase-8 Inhibitor II, Granzyme B Inhibitor III; Z-IE(OMe)TD(OMe)-FMK
• Empirische Formel (Hill-System): C₃₀H₄₃FN₄O₁₁
• Molekulargewicht: 654.68
• UNSPSC-Code: 12352200
• NACRES: NA.54

Eigenschaften

• Qualitätsniveau: 100
• Form: liquid
• Hersteller/Markenname: Calbiochem^®
• Lagerbedingungen: OK to freeze; desiccated (hygroscopic); protect from light
• Versandbedingung: wet ice
• Lagertemp.: −20°C

Beschreibung

Allgemeine Beschreibung

A 5 mM (250 µg/76 µl) solution of Z-IETD-FMK (Cat. No. 218759) in DMSO. Z-IETD-FMK is a potent, cell-permeable, and irreversible inhibitor of caspase-8 (MACH, FLICE, Mch5). Also inhibits granzyme B.

Biochem./physiol. Wirkung

Cell permeable: yes

Primary Target
caspase-8

Product does not compete with ATP.

Reversible: no

Verpackung

Packaged under inert gas

Warnhinweis

Toxicity: Irritant (B)

Sequenz

Z-Ile-Glu(OMe)-Thr-Asp(OMe)-CH₂F*

Physikalische Form

A 5 mM (250 µg/76 µl) solution of Z-IETD-FMK (Cat. No. 218759) in DMSO.

Rekonstituierung

Following initial thaw, aliquot and freeze (-20°C).

Hinweis zur Analyse

≥98% (HPLC)

Sonstige Hinweise

Martin, D.A., et al. 1998. J. Biol. Chem.273, 4345.
Sweeney, E.A., et al. 1998. FEBS Lett.425, 61.

Rechtliche Hinweise

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Sicherheitshinweise

• Lagerklassenschlüssel: 10 - Combustible liquids
• WGK: WGK 1
• Flammpunkt (°F): 188.6 °F - (refers to pure substance)
• Flammpunkt (°C): 87 °C - (refers to pure substance)