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Merck

790625P

Avanti

DC-Chol/DOPE Blend

Avanti Research - A Croda Brand 790625P, powder

Synonym(e):

DC-Chol/DOPE Blend, DC-Cholesterol/Dioleoyl Phosphatidylethanolamine (30:70, w/w)

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About This Item

UNSPSC-Code:
12352211
NACRES:
NA.25

Form

powder

Verpackung

pkg of 1 × 25 mg (790625P-25mg)

Hersteller/Markenname

Avanti Research - A Croda Brand 790625P

Lipid-Typ

cationic lipids
transfection

Versandbedingung

dry ice

Lagertemp.

−20°C

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Allgemeine Beschreibung

DC-Cholesterol/Dioleoyl Phosphatidylethanolamine (DOPE) lipid complex comprises the cationic lipid DC-Cholesterol and the neutral helper lipid DOPE.

Anwendung

DC-Chol/DOPE Blend has been used:
  • in the preparation of liposomes for ferritin heavy chain 1 (FTH1) siRNA (small interference RNA) transfection studies
  • to compare its cytotoxicity tests with ginger derived nanoparticles in colon-26 cells
  • as a standard control in MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide) assay to evaluate biocompatibility of ginger derived lipid vesicles

Biochem./physiol. Wirkung

DC-Cholesterol/Dioleoyl Phosphatidylethanolamine (30:70, w/w) helps in transfection of therapeutic small interference RNA (siRNA). DC-Chol/DOPE liposomes are cationic, unilamellar and spherical in nature. It aids in improved condensation of DNA for transfection studies.

Verpackung

5 mL Clear Glass Sealed Ampule (790625P-25mg)

Rechtliche Hinweise

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable


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Die Dokumentenbibliothek aufrufen

Mingzhen Zhang et al.
Nanomedicine (London, England), 12(16), 1927-1943 (2017-07-01)
To develop novel siRNA delivery system overcoming the limitations of synthetic nanoparticles, such as potential side effects, nonspecificity and economic production for ulcerative colitis therapy. Nanoparticles composed of edible ginger-derived lipid, termed ginger-derived lipid vehicles (GDLVs) were generated from ginger
Meike-Kristin Abraham et al.
Nanotheranostics, 1(2), 154-165 (2017-10-27)
Rationale: Genetic therapy using modified mRNA for specific therapeutic protein expression for disease treatment and vaccination represents a new field of therapeutic and diagnostic medicine. Non-viral vectors transfection using biocompatible nanoliposomes enables safe and efficient delivery of therapeutic mRNA. Objective:
Alberto Rodríguez-Pulido et al.
The journal of physical chemistry. B, 112(39), 12555-12565 (2008-08-30)
A 1:1 mixture of the cationic lipid 3beta-[ N-( N', N'-dimethylaminoethane)-carbamoyl]cholesterol hydrochloride (DC-Chol) and the zwitterionic lipid, 1,2-dioleoyl- sn-glycero-3-phosphoetanolamine (DOPE), has been used to compact calf-thymus DNA (CT-DNA) in aqueous buffered solution at 298.15 K. The formation process of this
Mingzhen Zhang et al.
Molecular therapy : the journal of the American Society of Gene Therapy, 24(10), 1783-1796 (2016-08-06)
The use of nanotechnology for drug delivery has shown great promise for improving cancer treatment. However, potential toxicity, hazardous environmental effects, issues with large-scale production, and potential excessive costs are challenges that confront their further clinical applications. Here, we describe
Vagisha Ravi et al.
PloS one, 14(9), e0221952-e0221952 (2019-09-07)
Elevated expression of the iron regulatory protein, ferritin heavy chain 1 (FTH1), is increasingly being associated with high tumor grade and poor survival outcomes in glioblastoma. Glioma initiating cells (GICs), a small population of stem-like cells implicated in therapeutic resistance

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