700015P

7-ketocholesterol

Avanti Research^™ - A Croda Brand

• Synonym(e): 7-oxocholesterol; 7-oxo-5-cholesten-3β-ol-7-one; 5-cholesten-3β-ol-7-one; 3β-hydroxycholest-5-en-7-one; 110806
• Empirische Formel (Hill-System): C₂₇H₄₄O₂
• CAS-Nummer: 566-28-9
• Molekulargewicht: 400.64
• UNSPSC-Code: 12352211
• NACRES: NA.25

Eigenschaften

• Beschreibung: 3β-hydroxy-5-cholestene-7-one
• Assay: >99% (TLC)
• Form: powder
• Verpackung: pkg of 1 × 100 mg (700015P-100mg); pkg of 1 × 5 mg (700015P-5mg); pkg of 1 × 50 mg (700015P-50mg)
• Hersteller/Markenname: Avanti Research^™ - A Croda Brand
• Versandbedingung: dry ice
• Lagertemp.: −20°C
• InChI: 1S/C27H44O2/c1-17(2)7-6-8-18(3)21-9-10-22-25-23(12-14-27(21,22)5)26(4)13-11-20(28)15-19(26)16-24(25)29/h16-18,20-23,25,28H,6-15H2,1-5H3/t18-,20+,21-,22+,23+,25+,26+,27-/m1/s1
• InChIKey: YIKKMWSQVKJCOP-ABXCMAEBSA-N

Beschreibung

Allgemeine Beschreibung

7-ketocholesterol is a major oxidation product of cholesterol.

Anwendung

<ul>
<li><strong>Cytoprotective effects of linolenic acid on 7-ketocholesterol-induced damage:</strong> This study highlights how specific fatty acids can mitigate the toxic effects of 7-ketocholesterol in neural and vascular cells, emphasizing potential therapeutic applications for neurodegenerative and cardiovascular diseases (Yammine et al., 2024).</li>
</ul>

Biochem./physiol. Wirkung

7-ketocholesterol is a strong inhibitor of cytochrome P450 7A1. It modulates cholesterol homeostasis, cytotoxicity and apoptosis. 7-ketocholesterol stimulates inflammation, growth inhibition and vascular endothelial growth factor. Cellular accumulation of 7-ketocholesterol enhances oxidative stress, endoplasmic reticulum stress and apoptosis in macrophages.

Verpackung

5 mL Amber Glass Screw Cap Vial (700015P-100mg)

5 mL Amber Glass Screw Cap Vial (700015P-50mg)

5 mL Amber Glass Screw Cap Vial (700015P-5mg)

Rechtliche Hinweise

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable