902543

Propargyl-PEG4-acid

• Synonym(e): 4,7,10,13-Tetraoxahexadec-15-ynoic acid, Propargyl-PEG4-CH₂CO₂H
• Empirische Formel (Hill-System): C₁₂H₂₀O₆
• CAS-Nummer: 1415800-32-6
• Molekulargewicht: 260.28
• MDL-Nummer: MFCD22683284
• UNSPSC-Code: 12352106
• NACRES: NA.22

Eigenschaften

• Form: liquid
• Eignung der Reaktion: reagent type: linker
• Verfügbarkeit: available only in USA
• Brechungsindex: n/D 1.460
• Dichte: 1.164 g/mL
• Funktionelle Gruppe: alkyne; carboxylic acid
• Lagertemp.: −20°C
• SMILES String: OC(CCOCCOCCOCCOCC#C)=O

Beschreibung

Anwendung

This heterobifunctional, PEGylated crosslinker features a carboxylic acid at one end and propargyl group at the other for reaction with azide-containing compounds using click chemistry. The hydrophillic PEG linker facilitates solubility in biological applications. Propargyl-PEG4-acid can be used for bioconjugation or as a building block for synthesis of small molecules, conjugates of small molecules and/or biomolecules, or other tool compounds for chemical biology and medicinal chemistry that require ligation. Examples of applications include its synthetic incorporation into antibody-drug conjugates or proteolysis-targeting chimeras (PROTAC^® molecules) for targeted protein degradation.

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Sonstige Hinweise

Design, Synthesis, and Evaluation of Novel 1,2,3-Triazole-Tethered Glycolipids as Vaccine Adjuvants

Rechtliche Hinweise

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

Sicherheitshinweise

• Piktogramme: GHS02
• Signalwort: Danger
• H-Sätze: H242
• P-Sätze: P210 - P234 - P235 - P240 - P370 + P378 - P403
• Gefahreneinstufungen: Self-react. C
• Lagerklassenschlüssel: 5.2 - Organic peroxides and self-reacting hazardous materials
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable