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Poly(lactide-co-glycolide)-block-poly(ethylene glycol)-block-poly(lactide-co-glycolide)
average Mn (1100-1000-1100), lactide:glycolide 75:25
Synonym(e):
PLGA-PEG-PLGA
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About This Item
UNSPSC-Code:
12162002
NACRES:
NA.23
Empfohlene Produkte
Beschreibung
typical PEG PDI<1.1; overall PDI≤2.0 (THF, PS)
Qualitätsniveau
Form
semisolid
Zufuhrverhältnis
lactide:glycolide 75:25
Mol-Gew.
PEG average Mn 1,000
PLGA average Mn 2,200
average Mn (1100-1000-1100)
Zeitrahmen für den Abbau
2-3 weeks
Übergangstemp.
Tm 230-235 °C
PDI
<2.0
Lagertemp.
2-8°C
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Allgemeine Beschreibung
PLGA-PEG-PLGA is an amphiphilic triblock copolymer which can self-assemble into micelles in aqueous medium due to the hydrophobic interactions present in the hydrophobic segments. The PEG segment imparts hydrophilicity and improves the biocompatibility of the copolymer. The PLGA segment forms a hydrophobic core and can solubilize hydrophobic drugs. These copolymers are widely used as nanocarriers for the sustained release of drugs.
Anwendung
Used in the synthesis of targeted nanoparticles which are used for differential delivery and controlled release of drugs.
Leistungsmerkmale und Vorteile
Biocompatible, degradable, thermosensitive, high stability, small size (<200 nm) and properties can be easily modified.
Lagerklassenschlüssel
11 - Combustible Solids
WGK
WGK 3
Flammpunkt (°F)
Not applicable
Flammpunkt (°C)
Not applicable
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The aim of this study was to assess the potential of new copolymeric micelles to modify the pharmacokenetics and tissue distribution of Curcumin (CUR), a hydrophobic drug. In the present study, a poly (d,l-lactide-co-glycolide)-b-poly(ethylene glycol)-b-poly(d,l-lactide-co-glycolide) (PLGA-PEG-PLGA) copolymer was synthesized and
Frank Gu et al.
Proceedings of the National Academy of Sciences of the United States of America, 105(7), 2586-2591 (2008-02-15)
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