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Poly(ethylene glycol) methyl ether-block-poly(lactide-co-glycolide)
PEG average Mn 5,000, PLGA Mn 55,000
Synonym(e):
PEG-PLGA, Polyethylene glycol, mPEG-b-PLGA, mPEG-b-PLGA
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About This Item
Lineare Formel:
H[(C3H4O2)x(C2H2O2)y]mO[C2H4O]nCH3
UNSPSC-Code:
12162002
NACRES:
NA.23
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Beschreibung
typical PEG PDI < 1.1; overall PDI < 2.5
Qualitätsniveau
Form
pellets
Zufuhrverhältnis
lactide:glycolide 50:50
Mol-Gew.
PEG average Mn 5,000
PLGA Mn 55,000
average Mn 60,000 (total)
Zeitrahmen für den Abbau
1-4 weeks
Übergangstemp.
Tg 10 °C(lit.)
Tm 254-259 °C
PDI
<1.2
Lagertemp.
2-8°C
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Allgemeine Beschreibung
Amphiphilic block copolymers (AmBC) are made up of two chemically different homopolymer blocks. One of the block is hydrophilic and the other one is hydrophobic. These macromolecules have the properties to self-assemble when dissolved in an aqueous media. PEG-PLGA is one the most commonly used biodegradable amphiphilic block copolymers for drug delivery applications. PEG is the hydrophilic part and PLGA is the hydrophobic part.
Anwendung
Used in the synthesis of targeted nanoparticles which are used for differential delivery and controlled release of drugs.
Leistungsmerkmale und Vorteile
- Good biocompatibility, low immunogenicity and good degradability.
- Properties can be easily modulated by changing the block copolymer segment sizes to suit a particular application.
Lagerklassenschlüssel
11 - Combustible Solids
WGK
WGK 3
Flammpunkt (°F)
Not applicable
Flammpunkt (°C)
Not applicable
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