730300
Methacrylsäure N-Hydroxysuccinimid-Ester
98%
Synonym(e):
N-(Methacryloxy)-succinimid, N-(Methacryloyloxy)-succinimid
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Alle Fotos(1)
About This Item
Empirische Formel (Hill-System):
C8H9NO4
CAS-Nummer:
Molekulargewicht:
183.16
MDL-Nummer:
UNSPSC-Code:
12162002
PubChem Substanz-ID:
NACRES:
NA.23
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Qualitätsniveau
Assay
98%
Form
solid
mp (Schmelzpunkt)
101-105 °C
Lagertemp.
2-8°C
SMILES String
CC(=C)C(=O)ON1C(=O)CCC1=O
InChI
1S/C8H9NO4/c1-5(2)8(12)13-9-6(10)3-4-7(9)11/h1,3-4H2,2H3
InChIKey
ACGJEMXWUYWELU-UHFFFAOYSA-N
Allgemeine Beschreibung
Methacrylic acid N-hydroxysuccinimide ester(NHS-MA) belongs to the class of reactive monomers known as N-hydroxysuccinimide (NHS) esters. It is commonly used for functionalizing biomolecules through amine-reactive coupling reactions infields such as bioconjugation, protein labeling, and peptide synthesis. It also serves as a crosslinking agent or linker molecule for the conjugation of drugs or targeting ligands to carrier materials.
Anwendung
Methacrylic acid N-hydroxysuccinimide ester can be used:
- As a monomer to prepare degradable amphiphilic diblock copolymer microparticles via RAFT polymerization, for low pH-triggered drug delivery. NHS-MA can shield the drug molecule from degradation, enhance its solubility, and improve its pharmacokinetic properties.
- For the surface functionalization of poly-ε-caprolactone (PCL) scaffolds used for tissue engineering. NHS groups are used to couple with chitosan of various molecular weights.
- To prepare biocompatible polymer hydrogel for enzymatic biofuel cells. The hydrogel can serve as an enzyme-immobilizing matrix for enzymatic bioelectrodes.
Signalwort
Warning
Gefahreneinstufungen
Acute Tox. 4 Inhalation - Eye Irrit. 2 - Skin Irrit. 2 - Skin Sens. 1 - STOT SE 3
Zielorgane
Respiratory system
Lagerklassenschlüssel
11 - Combustible Solids
WGK
WGK 3
Flammpunkt (°F)
Not applicable
Flammpunkt (°C)
Not applicable
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