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Isobutyramid
99%
Synonym(e):
2-Methylpropionamid
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Alle Fotos(3)
About This Item
Empfohlene Produkte
Qualitätsniveau
Assay
99%
Form
solid
bp
216-220 °C (lit.)
mp (Schmelzpunkt)
127-131 °C (lit.)
Dichte
1.013 g/mL at 25 °C (lit.)
Funktionelle Gruppe
amide
SMILES String
CC(C)C(N)=O
InChI
1S/C4H9NO/c1-3(2)4(5)6/h3H,1-2H3,(H2,5,6)
InChIKey
WFKAJVHLWXSISD-UHFFFAOYSA-N
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Anwendung
Isobutyramide was used for chemical grafting of human serum albumin during the synthesis of sequentialy assembled protein capsules.
Biochem./physiol. Wirkung
Isobutyramide activates transcription of human gamma-globin gene and murine embryonic epsilon(y)-globin gene. It is useful in the treatment of β-thalassemia and sickle cell disease.
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ACS nano, 6(9), 7584-7594 (2012-09-07)
We report the sequential assembly of proteins via the alternating physical adsorption of human serum albumin (HSA) and chemical grafting with isobutyramide (IBAM) or bromoisobutyramide (BrIBAM) groups. This approach, performed on silica template particles, leads to the formation of noncovalent
European journal of biochemistry, 241(2), 546-551 (1996-10-15)
The coordination geometry of the metal at the active site in Cd-substituted horse liver alcohol dehydrogenase (LADH) has been investigated for the binary complexes of LADH with imidazole, isobutyramide, decanoic acid and Cl-, and for the ternary complexes of LADH
Experientia, 49(2), 133-137 (1993-02-15)
The inherited beta-hemoglobinopathies (sickle cell disease and beta thalassemia) are the result of a mutation in the adult (beta) globin gene. The fetal globin chain, encoded by the gamma globin genes, can substitute for the mutated or defective beta globin
Journal of molecular endocrinology, 25(1), 129-139 (2000-07-29)
To determine if ketoacidosis contributes to reduced apolipoprotein A1 (apoA1) expression in insulin-deficient diabetic rats, we examined the regulation of apoA1 gene expression in response to changes in ambient pH or ketone body concentrations. Hepatic apoAI mRNA levels were reduced
British journal of haematology, 88(3), 555-561 (1994-11-01)
Butyrate and other short-chain fatty acids stimulate fetal globin gene expression and have potential for ameliorating the beta globin disorders. Butyrate, however, is rapidly metabolized in vivo and reaches only micromolar concentrations in plasma. We report here that a branched-chain
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