276375

1,5-Naphthalenedisulfonic acid tetrahydrate

97%

• Synonym(s): Armstrong’s acid
• Linear Formula: C₁₀H₆(SO₃H)₂·4H₂O
• CAS Number: 211366-30-2
• Molecular Weight: 360.36
• EC Number: 201-317-9
• MDL number: MFCD00149265
• UNSPSC Code: 12352100
• PubChem Substance ID: 24856706
• NACRES: NA.22

Properties

• Assay: 97%
• form: solid
• functional group: sulfonic acid
• SMILES string: O.O.O.O.OS(=O)(=O)c1cccc2c(cccc12)S(O)(=O)=O
• InChI: 1S/C10H8O6S2.4H2O/c11-17(12,13)9-5-1-3-7-8(9)4-2-6-10(7)18(14,15)16;;;;/h1-6H,(H,11,12,13)(H,14,15,16);4*1H2
• InChI key: ZLBLYGIIADHDKG-UHFFFAOYSA-N

Description

General description

1,5-Naphthalenedisulfonic acid tetrahydrate reacts with [n-Bu₂SnO]_n in a 1:1 stoichiometry followed by reaction with 2,2′-bipyridine-N,N′-dioxide (BPDO-I) to yield 1D-coordination polymer, [n-Bu₂Sn(BPDO-I)(1,5-C₁₀H₆(SO₃)₂)]_n.

Application

• Assessment of verapamil in a myotonic dystrophy model: Research demonstrated verapamil′s efficacy in mitigating chloride and calcium channel dysfunctions in a myotonic dystrophy mouse model, suggesting its potential in treating related muscular dystrophies (Cisco et al., 2024).



• Cardiac tissue modeling with verapamil: Verapamil hydrochloride was tested using human-induced pluripotent stem cell-derived cardiac tissues to evaluate drug interactions and cardiac responses, proving essential for advancing cardiac safety pharmacology (Miyagawa et al., 2024).

Safety Information

• Pictograms: GHS05
• Signal Word: Danger
• Hazard Statements: H314
• Precautionary Statements: P260 - P280 - P303 + P361 + P353 - P304 + P340 + P310 - P305 + P351 + P338 - P363
• Hazard Classifications: Eye Dam. 1 - Skin Corr. 1B
• Storage Class Code: 8A - Combustible corrosive hazardous materials
• WGK: WGK 3
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves