Key Documents

bpV(pic)

Name: bpV(pic)
Brand: SIGMA

≥95% V basis

Synonym(s):

Dipotassium Bisperoxovanadium(pic) dihydrate, Dipotassium bisperoxo (picolinato) oxovanadate (V) dihydrate, K₂ [VO(O₂)2C₆H₄NO₂] · 2 H₂O

Select a Size

Change View

Size/SKU	Availability	Price

About This Item

Empirical Formula (Hill Notation):

K₂VOO₂O₂C₆H₄NO₂ · 2H₂O

CAS Number:

148556-27-8

Molecular Weight:

367.27

NACRES:

NA.77

UNSPSC Code:

12352200

Assay:

≥95% V basis

Form:

powder

Storage condition:

protect from light

Pricing and availability is not currently available.

Technical Service

Need help? Our team of experienced scientists is here for you.

Let Us Assist

Properties

Quality Segment

100

assay

≥95% V basis

form

powder

storage condition

protect from light

color

faintly yellow to dark yellow

solubility

H₂O: 20 mg/mL, clear

storage temp.

−20°C

Description

Application

bpV(pic) has been used in cell culture treatment to study the route of activation of multiple pathways required for HERV (human endogenous retroviruses) transcription.

Biochem/physiol Actions

bpV(pic) is a bisperoxovanadium inhibitor of protein phosphotyrosine phosphatases with selectivity for phosphatase and tensin homolog (PTEN), a tumour suppressor phosphatase involved in cell cycle regulation. IC₅₀ values for bpV(pic) are 31 nM for PTEN compared to 12.7 μM for PTPβ and 61 μM for PTP-1β. bpV(pic) can also act as an insulin mimetic and activate insulin receptor kinase (IRK).

bpV(pic) is a bisperoxovanadium inhibitor of protein phosphotyrosine phosphatases with selectivity for phosphatase and tensin homolog (PTEN).

bpV(pic) contains a polar side chain, and specifically inhibits PTEN(phosphatase and tensin homolog) unlike its parent compound, which targets several other phosphatases too. Thus, making bpV(pic) more a prefered inhibitor. bpV(pic) is recognized as a potent activator of multiple sclerosis (an autoimmune disorder) related human endogenous retroviruses.

Other Notes

Light Sensitive

Compare Similar Items

View Full Comparison

Show Differences

1 of 1

This Item	SML0884	SML0889	203695
Sigma-Aldrich SML0885 bpV(pic)	Sigma-Aldrich SML0884 bpV(HOpic)	Sigma-Aldrich SML0889 bpV(phen)	Sigma-Aldrich 203695 bpV(phen)
description ≥95% V basis	description ≥90% V basis	description ≥95% V basis	description A potent protein phosphotyrosine phosphatase inhibitor and insulin receptor kinase (IRK) activator.
assay ≥95% V basis	assay ≥90% V basis	assay ≥95% V basis	assay ≥99% (⁵¹V-NMR)
form powder	form powder	form powder	form solid
Quality Level 100	Quality Level 100	Quality Level 100	Quality Level 100
storage temp. −20°C	storage temp. −20°C	storage temp. −20°C	storage temp. −20°C
solubility H₂O: 20 mg/mL, clear	solubility H₂O: 20 mg/mL, clear	solubility H₂O: 20 mg/mL, clear	solubility water: 5 mg/mL
storage condition protect from light	storage condition desiccated, protect from light	storage condition protect from light	storage condition OK to freeze, protect from light