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SML0889

bpV(phen)

≥95% V basis

Synonym(s):

Potassium bisperoxo(1,10-phenanthroline)oxovanadate (V) hydrate

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About This Item

Empirical Formula (Hill Notation):
KVO5C12H8N2 · xH2O
CAS Number:
Molecular Weight:
350.24 (anhydrous basis)
NACRES:
NA.77
UNSPSC Code:
12352200
Assay:
≥95% V basis
Form:
powder
Storage condition:
protect from light
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Quality Segment

assay

≥95% V basis

form

powder

storage condition

protect from light

color

faintly yellow to dark yellow

solubility

H2O: 20 mg/mL, clear

storage temp.

−20°C

SMILES string

O=[V]123([N]4=CC=CC5=C4C6=C(C=CC=[N]62)C=C5)(OO3)OO1.[K]

InChI

1S/C12H8N2.K.2H2O2.O.V/c1-3-9-5-6-10-4-2-8-14-12(10)11(9)13-7-1;;2*1-2;;/h1-8H;;2*1-2H;;/q;+1;;;;

InChI key

MQPXOTNOFVCXDA-UHFFFAOYSA-N

Biochem/physiol Actions

bpV(phen) is an insulin receptor kinase (IRK) activator and an inhibitor of protein phosphotyrosine phosphatases with selectivity for PTEN, phosphatase and tensin homolog, a tumour suppressor phosphatase involved in cell cycle regulation. IC50 values for bpV(phen) are 38 nM for PTEN compared to 343 nM for PTPβ and 920 nM for PTP-1β. bpV(phen) has anti-inflammatory effects in oxidative stress including inhibitory effects on oxidative stress-induced cardiomyocyte injury that may be partially modulated by the action of ROS on PTEN. It may also be involved in differentiation.
bpV(phen) is an insulin receptor kinase (IRK) activator and an inhibitor of protein phosphotyrosine phosphatases with selectivity for PTEN.
bpV(phen) (potassium bisperoxo(bipyridine)oxovanadate) shows protective effect against disease progression in leishmaniasis by mediating NO-dependent microbicidal action.

Other Notes

Light Sensitive

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This Item
203695203694203701
description

≥95% V basis

description

A potent protein phosphotyrosine phosphatase inhibitor and insulin receptor kinase (IRK) activator.

description

A potent inhibitor of phosphotyrosine phosphatase (Ki = 100 nM for insulin receptor dephosphorylation).

description

A potent phosphotyrosine phosphatase inhibitor.

form

powder

form

solid

form

solid

form

solid

assay

≥95% V basis

assay

≥99% (51V-NMR)

assay

≥95% (51V-NMR)

assay

≥70% (51V-NMR)

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

solubility

H2O: 20 mg/mL, clear

solubility

water: 5 mg/mL

solubility

water: 5 mg/mL

solubility

water: 4 mg/mL

storage condition

protect from light

storage condition

protect from light, OK to freeze

storage condition

OK to freeze, protect from light

storage condition

OK to freeze, protect from light


pictograms

Exclamation mark

signalword

Warning

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable



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