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10058-F4

Name: 10058-F4
Brand: SIGMA

≥98% (HPLC), c-Myc inhibitor, solid

Synonym(s):

5-[(4-Ethylphenyl)methylene]-2-thioxo-4-thiazolidinone

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About This Item

Empirical Formula (Hill Notation):

C₁₂H₁₁NOS₂

CAS Number:

403811-55-2

Molecular Weight:

249.35

UNSPSC Code:

12352200

PubChem Substance ID:

329799701

NACRES:

NA.77

MDL number:

MFCD00758517

Assay:

≥98% (HPLC)

Form:

solid

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Properties

Product Name

10058-F4, ≥98% (HPLC), solid

Quality Segment

100

assay

≥98% (HPLC)

form

solid

color

yellow

solubility

DMSO: >10 mg/mL, H₂O: <2 mg/mL

storage temp.

2-8°C

SMILES string

CCc1ccc(cc1)\C=C2\SC(=S)NC2=O

InChI

1S/C12H11NOS2/c1-2-8-3-5-9(6-4-8)7-10-11(14)13-12(15)16-10/h3-7H,2H2,1H3,(H,13,14,15)/b10-7+

InChI key

SVXDHPADAXBMFB-JXMROGBWSA-N

Description

Application

10058-F4 has been used:

as c-Myc inhibitor to treat stromal cells
as c-Myc inhibitor to determine the effect of c-Myc inhibition on cardiac progenitor cells (CPC) growth
as c-Myc inhibitor to culture T cells
to treat C4-2 cells to examine the activity of MST1 promoter luciferase reporter construct

Biochem/physiol Actions

10058-F4 is a c-Myc inhibitor that induces cell-cycle arrest and apoptosis. 10058-F4 is a cell-permeable thiazolidinone that specificallly inhibits the c-Myc-Max interaction and prevents transactivation of c-Myc target gene expression. 10058-F4 inhibits tumor cell growth in a c-Myc-dependent manner both in vitro and in vivo (64 μM using c-Myc transfected Rat1a fibroblasts).

10058-F4 is a c-Myc inhibitor.

Features and Benefits

This compound is a featured product for Gene Regulation research. Click here to discover more featured Gene Regulation products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

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Show Differences

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This Item	A0231	SML1735	SML1733
Sigma-Aldrich F3680 10058-F4	Sigma-Aldrich A0231 AS 604850	Sigma-Aldrich SML1735 PFM01	Sigma-Aldrich SML1733 FINDY
description ≥98% (HPLC), solid	description ≥98% (HPLC), solid	description ≥98% (HPLC)	description ≥98% (HPLC)
form solid	form solid	form powder	form powder
assay ≥98% (HPLC)	assay ≥98% (HPLC)	assay ≥98% (HPLC)	assay ≥98% (HPLC)
Quality Level 100	Quality Level 100	Quality Level 100	Quality Level 100
storage temp. 2-8°C	storage temp. 2-8°C	storage temp. 2-8°C	storage temp. 2-8°C
solubility H₂O: <2 mg/mL, DMSO: >10 mg/mL	solubility H₂O: <2 mg/mL, DMSO: >10 mg/mL	solubility DMSO: 20 mg/mL, clear	solubility DMSO: 25 mg/mL, clear
color yellow	color off-white	color white to beige	color light yellow to dark yellow

pictograms

GHS07

signalword

Warning

hcodes

H317,H319

pcodes

P280 - P302 + P352 - P305 + P351 + P338

Hazard Classifications

Eye Irrit. 2 - Skin Sens. 1

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

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